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Ten things you should know about transposable elements Bourque, Guillaume; Burns, Kathleen H; Gehring, Mary; Gorbunova, Vera; Seluanov, Andrei; Hammell, Molly; Imbeault, Michaël; Izsvák, Zsuzsanna; Levin, Henry L; Macfarlan, Todd S; Mager, Dixie L; Feschotte, Cédric
Abstract
Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.
Item Metadata
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Ten things you should know about transposable elements
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Creator | |
Publisher |
BioMed Central
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Date Issued |
2018-11-19
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Description |
Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.
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Genre | |
Type | |
Language |
eng
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Date Available |
2018-11-22
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution 4.0 International (CC BY 4.0)
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DOI |
10.14288/1.0374202
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URI | |
Affiliation | |
Citation |
Genome Biology. 2018 Nov 19;19(1):199
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Publisher DOI |
10.1186/s13059-018-1577-z
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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Copyright Holder |
The Author(s).
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DSpace
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Item Media
Item Citations and Data
Rights
Attribution 4.0 International (CC BY 4.0)