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The global burden of sepsis: barriers and potential solutions Rudd, Kristina E; Kissoon, Niranjan; Limmathurotsakul, Direk; Bory, Sotharith; Mutahunga, Birungi; Seymour, Christopher W; Angus, Derek C; West, T. E

Abstract

Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy.

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Title
The global burden of sepsis: barriers and potential solutions
Creator
Rudd, Kristina E; Kissoon, Niranjan; Limmathurotsakul, Direk; Bory, Sotharith; Mutahunga, Birungi; Seymour, Christopher W; Angus, Derek C; West, T. E
Contributor
Children's Hospital (Vancouver, B.C.)
Publisher
BioMed Central
Date Issued
2018-09-23
Description
Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy.
Subject
Health resources; Poverty; Public health; Sepsis; Low-income countries
Genre
Article
Type
Text
Language
eng
Date Available
2018-09-24
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0372147
URI
http://hdl.handle.net/2429/67244
Affiliation
Medicine, Faculty of; Other UBC; Non UBC; Medicine, Department of; Pediatrics, Department of
Citation
Critical Care. 2018 Sep 23;22(1):232
Publisher DOI
10.1186/s13054-018-2157-z
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)