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The diagnostic performance of patient symptoms in screening for COPD Johnson, Kate M; Tan, Wan C; Bourbeau, Jean; Sin, Don D; Sadatsafavi, Mohsen

Abstract

It is recommended that screening for COPD be restricted to symptomatic individuals, but supporting evidence is lacking. We determined the performance of wheeze, cough, phlegm, and dyspnea in discriminating COPD versus non-COPD in a population-based sample of 1332 adults. Area Under the Receiver Operating Curves (AUC) indicated that symptoms had modest performance whether assessed individually (AUCs 0.55–0.62), or in combination (AUC for number of symptoms as the predictor 0.64). AUC improved with the inclusion of multiple other factors (AUC 0.71). Restricting screening to symptomatic individuals is unlikely to substantially improve the yield of general population screening for undiagnosed COPD.

Item Metadata

Title
The diagnostic performance of patient symptoms in screening for COPD
Creator
Johnson, Kate M; Tan, Wan C; Bourbeau, Jean; Sin, Don D; Sadatsafavi, Mohsen
Contributor
University of British Columbia. Collaboration for Outcomes Research and Evaluation; University of British Columbia. Centre for Heart Lung Innovation; James Hogg iCAPTURE Centre (University of British Columbia); St. Paul's Hospital (Vancouver, B.C.); Institute for Heart Lung Health
Publisher
BioMed Central
Date Issued
2018-08-03
Description
It is recommended that screening for COPD be restricted to symptomatic individuals, but supporting evidence is lacking. We determined the performance of wheeze, cough, phlegm, and dyspnea in discriminating COPD versus non-COPD in a population-based sample of 1332 adults. Area Under the Receiver Operating Curves (AUC) indicated that symptoms had modest performance whether assessed individually (AUCs 0.55–0.62), or in combination (AUC for number of symptoms as the predictor 0.64). AUC improved with the inclusion of multiple other factors (AUC 0.71). Restricting screening to symptomatic individuals is unlikely to substantially improve the yield of general population screening for undiagnosed COPD.
Subject
Screening test; Population; Respiratory symptoms; Chronic obstructive pulmonary disease
Genre
Article
Type
Text
Language
eng
Date Available
2018-08-09
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0370938
URI
http://hdl.handle.net/2429/66705
Affiliation
Medicine, Faculty of; Pharmaceutical Sciences, Faculty of; Other UBC; Non UBC; Medicine, Department of
Citation
Respiratory Research. 2018 Aug 03;19(1):147
Publisher DOI
10.1186/s12931-018-0853-5
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)