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Hippocampal learning, memory, and neurogenesis : effects of sex and estrogens across the lifespan in adults Duarte-Guterman, Paula; Yagi, Shunya; Chow, Carmen; Galea, Liisa A. M.

Abstract

There are sex differences in hippocampus-dependent cognition and neurogenesis suggesting that sex hormones are involved. Estrogens modulate certain forms of spatial and contextual memory and neurogenesis in the adult female rodent, and to a lesser extent male, hippocampus. This review focuses on the effects of sex and estrogens on hippocampal learning, memory, and neurogenesis in the young and aged adult rodent. We discuss how factors such as the type of estrogen, duration and dose of treatment, timing of treatment and type of memory influence the effects of estrogens on cognition and neurogenesis. We also address how reproductive experience (pregnancy and mothering) and aging interact with estrogens to modulate hippocampal cognition and neurogenesis in females. Given the evidence that adult hippocampal neurogenesis plays a role in long-term spatial memory and pattern separation, we also discuss the functional implications of regulating neurogenesis in the hippocampus.

Item Metadata

Title
Hippocampal learning, memory, and neurogenesis : effects of sex and estrogens across the lifespan in adults
Creator
Duarte-Guterman, Paula; Yagi, Shunya; Chow, Carmen; Galea, Liisa A. M.
Contributor
University of British Columbia. Graduate Program in Neuroscience; Djavad Mowafaghian Centre for Brain Health
Date Issued
2015
Description
There are sex differences in hippocampus-dependent cognition and neurogenesis suggesting that sex hormones are involved. Estrogens modulate certain forms of spatial and contextual memory and neurogenesis in the adult female rodent, and to a lesser extent male, hippocampus. This review focuses on the effects of sex and estrogens on hippocampal learning, memory, and neurogenesis in the young and aged adult rodent. We discuss how factors such as the type of estrogen, duration and dose of treatment, timing of treatment and type of memory influence the effects of estrogens on cognition and neurogenesis. We also address how reproductive experience (pregnancy and mothering) and aging interact with estrogens to modulate hippocampal cognition and neurogenesis in females. Given the evidence that adult hippocampal neurogenesis plays a role in long-term spatial memory and pattern separation, we also discuss the functional implications of regulating neurogenesis in the hippocampus.
Subject
Hippocampus; Adult neurogenesis; Dentate gyrus; Cognition; Sex differences; Reproductive experience; Aging; Estrogen receptor
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2018-07-30
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0369246
URI
http://hdl.handle.net/2429/66620
Affiliation
Arts, Faculty of; Medicine, Faculty of; Psychology, Department of
Citation
Duarte-Guterman, P., Yagi, S., Chow, C., & Galea, L. A. M. (2015). Hippocampal learning, memory, and neurogenesis: Effects of sex and estrogens across the lifespan in adults. Hormones and Behavior, 74, 37-52.
Publisher DOI
10.1016/j.yhbeh.2015.05.024
Peer Review Status
Reviewed
Scholarly Level
Faculty; Postdoctoral; Graduate
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International