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Methadone maintenance therapy and viral suppression among HIV-infected opioid users: the impacts of crack and injection cocaine use Socias, M. Eugenia; Wood, Evan; Small, Will; Dong, Huiru; Shoveller, Jean; Kerr, Thomas; Montaner, Julio; Milloy, M-J

Abstract

Background—Methadone maintenance therapy (MMT) is associated with improved HIV treatment outcomes among people who use drugs (PWUD). The extent to which these benefits are sustained in the context of ongoing cocaine use is unclear. We assessed differential impacts of MMT on HIV viral load (VL) suppression in relation to discrete patterns of cocaine use. Methods—Data was drawn from ACCESS, a prospective cohort of HIV-positive PWUD in Vancouver, Canada. Generalized linear mixed-effects were used to model the independent effect of MMT on VL suppression across strata of frequency of cocaine injection and crack smoking (≥daily versus

Item Metadata

Title
Methadone maintenance therapy and viral suppression among HIV-infected opioid users: the impacts of crack and injection cocaine use
Creator
Socias, M. Eugenia; Wood, Evan; Small, Will; Dong, Huiru; Shoveller, Jean; Kerr, Thomas; Montaner, Julio; Milloy, M-J
Contributor
British Columbia Centre for Excellence in HIV/AIDS
Date Issued
2016-11
Description
Background—Methadone maintenance therapy (MMT) is associated with improved HIV treatment outcomes among people who use drugs (PWUD). The extent to which these benefits are sustained in the context of ongoing cocaine use is unclear. We assessed differential impacts of MMT on HIV viral load (VL) suppression in relation to discrete patterns of cocaine use. Methods—Data was drawn from ACCESS, a prospective cohort of HIV-positive PWUD in Vancouver, Canada. Generalized linear mixed-effects were used to model the independent effect of MMT on VL suppression across strata of frequency of cocaine injection and crack smoking (≥daily versus
Subject
opioid substitution treatment; methadone maintenance therapy; antiretroviral therapy; cocaine; viral suppression; opioid use disorder
Geographic Location
Downtown-Eastside (Vancouver, B.C.)
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2018-07-12
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0368912
URI
http://hdl.handle.net/2429/66485
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of; Population and Public Health (SPPH), School of
Citation
Socías, M. E., Wood, E., Small, W., Dong, H., Shoveller, J., Kerr, T., ... & Milloy, M. J. (2016). Methadone maintenance therapy and viral suppression among HIV-infected opioid users: the impacts of crack and injection cocaine use. Drug & Alcohol Dependence, 168, 211-218.
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International