UBC Faculty Research and Publications

Methadone maintenance therapy and viral suppression among HIV-infected opioid users: the impacts of crack and injection cocaine use Socias, M. Eugenia; Wood, Evan; Small, Will; Dong, Huiru; Shoveller, Jean; Kerr, Thomas; Montaner, Julio; Milloy, M-J

Abstract

Background—Methadone maintenance therapy (MMT) is associated with improved HIV treatment outcomes among people who use drugs (PWUD). The extent to which these benefits are sustained in the context of ongoing cocaine use is unclear. We assessed differential impacts of MMT on HIV viral load (VL) suppression in relation to discrete patterns of cocaine use. Methods—Data was drawn from ACCESS, a prospective cohort of HIV-positive PWUD in Vancouver, Canada. Generalized linear mixed-effects were used to model the independent effect of MMT on VL suppression across strata of frequency of cocaine injection and crack smoking (≥daily versus

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