Open Collections

N2O strongly prevents adhesion formation and postoperative pain in open surgery through a drug-like effect

Springer Berlin Heidelberg

Background: Microsurgical tenets and peritoneal conditioning during laparoscopic surgery (LS) decrease postoperative adhesions and pain. For a trial in human, the strong beneficial effects of N2O needed to be confirmed in open surgery (OS). Results: In a mouse model for OS, the effect of the gas environment upon adhesions was evaluated. Experiment I evaluated desiccation and the duration of exposure to CO2, N2O or CO2 + 4%O2. Experiment II evaluated the dose-response curve of adding N2O to CO2. Experiment III compared humidified CO2 + 10% N2O during LS and OS. In OS, 30- and 60-min exposure to non-humidified CO2 caused mortality of 33 and 100%, respectively. Mortality was prevented by humidification, by dry N2O or dry CO2 + 4%O2. Adhesions increased with the duration of exposure to CO2 (p < 0.0001) and decreased slightly by humidification or by the addition of 4% O2. N2O strongly decreased adhesions at concentrations of 5% or greater. With humidified CO2 + 10% N2O, adhesion formation was similar in OS and LS. Conclusions: The drug-like and strong beneficial effect of low concentrations of N2O is confirmed in OS.

Article

eng

Vancouver : University of British Columbia Library

10.14288/1.0368603

Medicine, Faculty of; Non UBC; Obstetrics and Gynaecology, Department of

10.1186/s10397-017-1024-2

Faculty

http://creativecommons.org/licenses/by/4.0/