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New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care Talhouk, A.; McAlpine, J. N

Abstract

Endometrial carcinoma (EC) is the fourth most common cancer in women in the developed world. Classification of ECs by histomorphologic criteria has limited reproducibility and better tools are needed to distinguish these tumors and enable a subtype-specific approach to research and clinical care. Based on the Cancer Genome Atlas, two research teams have developed pragmatic molecular classifiers that identify four prognostically distinct molecular subgroups. These methods can be applied to diagnostic specimens (e.g., endometrial biopsy) with the potential to completely change the current risk stratification systems and enable earlier informed decision making. The evolution of genomic classification in ECs is shared herein, as well as potential applications and discussion of the essential research still needed in order to optimally integrate molecular classification in to current standard of care.

Item Metadata

Title
New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care
Creator
Talhouk, A.; McAlpine, J. N
Publisher
BioMed Central
Date Issued
2016-12-13
Description
Endometrial carcinoma (EC) is the fourth most common cancer in women in the developed world. Classification of ECs by histomorphologic criteria has limited reproducibility and better tools are needed to distinguish these tumors and enable a subtype-specific approach to research and clinical care. Based on the Cancer Genome Atlas, two research teams have developed pragmatic molecular classifiers that identify four prognostically distinct molecular subgroups. These methods can be applied to diagnostic specimens (e.g., endometrial biopsy) with the potential to completely change the current risk stratification systems and enable earlier informed decision making. The evolution of genomic classification in ECs is shared herein, as well as potential applications and discussion of the essential research still needed in order to optimally integrate molecular classification in to current standard of care.
Subject
Endometrial carcinoma; Histotype; The Cancer Genome Atlas (TCGA); Risk stratification; Prognosis; POLE mutations; Mismatch repair deficiencies; p53; Molecular classification
Genre
Article
Type
Text
Language
eng
Date Available
2018-06-07
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0368589
URI
http://hdl.handle.net/2429/66262
Affiliation
Medicine, Faculty of; Non UBC; Obstetrics and Gynaecology, Department of; Pathology and Laboratory Medicine, Department of
Citation
Gynecologic Oncology Research and Practice. 2016 Dec 13;3(1):14
Publisher DOI
10.1186/s40661-016-0035-4
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)