UBC Faculty Research and Publications

Rationale and Design of the CREDENCE Trial: computed TomogRaphic evaluation of atherosclerotic DEtermiNants of myocardial IsChEmia Rizvi, Asim; Hartaigh, Bríain ó; Knaapen, Paul; Leipsic, Jonathon; Shaw, Leslee J; Andreini, Daniele; Pontone, Gianluca; Raman, Subha; Khan, Muhammad A; Ridner, Michael; Nabi, Faisal; Gimelli, Alessia; Jang, James; Cole, Jason; Nakazato, Ryo; Zarins, Christopher; Han, Donghee; Lee, Ji H; Szymonifika, Jackie; Gomez, Millie J; Truong, Quynh A; Chang, Hyuk-Jae; Lin, Fay Y; Min, James K

Abstract

Background: Coronary computed tomography angiography (CCTA) allows for non-invasive assessment of obstructive coronary artery disease (CAD) beyond measures of stenosis severity alone. This assessment includes atherosclerotic plaque characteristics (APCs) and calculation of fractional flow reserve (FFR) from CCTA (FFRCT). Similarly, stress imaging by myocardial perfusion scintigraphy (MPS) provides vital information. To date, the diagnostic performance of integrated CCTA assessment versus integrated MPS assessment for diagnosis of vessel-specific ischemia remains underexplored. Methods: CREDENCE will enroll adult individuals with symptoms suspicious of CAD referred for non-emergent invasive coronary angiography (ICA), but without known CAD. All participants will undergo CCTA, MPS, ICA and FFR. FFR will be performed for lesions identified at the time of ICA to be ≥40 and

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