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Heterogeneity of respiratory distress syndrome: risk factors and morbidity associated with early and late gestation disease Mehrabadi, Azar; Lisonkova, Sarka; Joseph, K. S.
Abstract
Background: Although respiratory distress syndrome (RDS) is considered a disease of prematurity, there is evidence to suggest heterogeneity between early and late gestation RDS. We examined the epidemiologic features of RDS occurring at early and late gestation. Methods: We conducted a retrospective cohort study including live births in the United States in 2005–06, with information obtained from the National Center for Health Statistics. Early (<32 weeks) and late gestation RDS (≥39 weeks) were contrasted in terms of risk factors and associations with pregnancy complications, obstetric intervention and co-morbidity. Logistic regression was used to quantify the effects of risk factors, while other associations were quantified descriptively. Results: There were 27,971 RDS cases, yielding an incidence of 6.4 per 1000 live births. Early and late gestation RDS differed in terms of risk factors, with factors such as multi-fetal gestation more strongly associated with early (adjusted odds ratio [aOR] 11.6, 95 % confidence interval 11.0–12.2) compared with late gestation RDS (aOR 3.66, 95 % confidence interval 2.68–4.98). The morbidity correlates of early and late gestation RDS also differed substantially; neonatal seizures were less strongly associated with early (OR 5.90, 95 % confidence interval 3.67–9.47) compared with late gestation RDS (OR 33.1, 95 % confidence interval 27.2–40.2), while meconium aspiration syndrome was not significantly associated with early gestation RDS (OR 1.87, 95 % confidence interval 0.94–3.72) and very strongly associated with late gestation RDS (OR 39.8, 95 % confidence interval 34.7–45.6). Conclusions: Differences in risk factors and morbidity correlates of early and late gestation RDS suggest that these entities represent two distinct diseases.
Item Metadata
Title |
Heterogeneity of respiratory distress syndrome: risk factors and morbidity associated with early and late gestation disease
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Creator | |
Contributor | |
Publisher |
BioMed Central
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Date Issued |
2016-09-27
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Description |
Background:
Although respiratory distress syndrome (RDS) is considered a disease of prematurity, there is evidence to suggest heterogeneity between early and late gestation RDS. We examined the epidemiologic features of RDS occurring at early and late gestation.
Methods:
We conducted a retrospective cohort study including live births in the United States in 2005–06, with information obtained from the National Center for Health Statistics. Early (<32 weeks) and late gestation RDS (≥39 weeks) were contrasted in terms of risk factors and associations with pregnancy complications, obstetric intervention and co-morbidity. Logistic regression was used to quantify the effects of risk factors, while other associations were quantified descriptively.
Results:
There were 27,971 RDS cases, yielding an incidence of 6.4 per 1000 live births. Early and late gestation RDS differed in terms of risk factors, with factors such as multi-fetal gestation more strongly associated with early (adjusted odds ratio [aOR] 11.6, 95 % confidence interval 11.0–12.2) compared with late gestation RDS (aOR 3.66, 95 % confidence interval 2.68–4.98). The morbidity correlates of early and late gestation RDS also differed substantially; neonatal seizures were less strongly associated with early (OR 5.90, 95 % confidence interval 3.67–9.47) compared with late gestation RDS (OR 33.1, 95 % confidence interval 27.2–40.2), while meconium aspiration syndrome was not significantly associated with early gestation RDS (OR 1.87, 95 % confidence interval 0.94–3.72) and very strongly associated with late gestation RDS (OR 39.8, 95 % confidence interval 34.7–45.6).
Conclusions:
Differences in risk factors and morbidity correlates of early and late gestation RDS suggest that these entities represent two distinct diseases.
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Subject | |
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Type | |
Language |
eng
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Date Available |
2018-05-15
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution 4.0 International (CC BY 4.0)
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DOI |
10.14288/1.0366846
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URI | |
Affiliation | |
Citation |
BMC Pregnancy and Childbirth. 2016 Sep 27;16(1):281
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Publisher DOI |
10.1186/s12884-016-1085-7
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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Copyright Holder |
The Author(s).
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Citations and Data
Rights
Attribution 4.0 International (CC BY 4.0)