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Cardiovascular risk is similar in patients with glomerulonephritis compared to other types of chronic kidney disease: a matched cohort study Hutton, Holly L.; Levin, A. (Adeera); Gill, Jagbir; Djurdjev, Ognjenka; Tang, Mila; Barbour, Sean J.

Abstract

Background: Patients with chronic kidney disease (CKD) due to glomerulonephritis (GN) are thought to be at high risk for cardiovascular disease (CVD). However, no study has examined whether GN directly contributes to CV risk beyond the effects conferred by pre-existing traditional risk factors and level of renal function. Methods: Matched cohort study using the previously described prospective CanPREDDICT study cohort. 2187 patients with CKD (eGFR 15–45 ml/min/m2) from 25 Canadian centres were divided into GN vs non-GN cause of CKD. Patients on immunotherapy for GN were not included in the study. Standardized measures of CV risk factors, biomarkers and CV outcomes were recorded over 3 years of follow-up, with the primary outcome measure being time to first all-cause CV event. Results: In the overall cohort, CV events occurred in 25 (8.7%) of the GN group and 338 (17.8%) of the non-GN group (HR 0.45, 95% CI 0.30–0.67, p 

Item Metadata

Title
Cardiovascular risk is similar in patients with glomerulonephritis compared to other types of chronic kidney disease: a matched cohort study
Creator
Hutton, Holly L.; Levin, A. (Adeera); Gill, Jagbir; Djurdjev, Ognjenka; Tang, Mila; Barbour, Sean J.
Contributor
Centre for Health Evaluation & Outcome Sciences; St. Paul's Hospital (Vancouver, B.C.)
Publisher
BioMed Central
Date Issued
2017-03-20
Description
Background: Patients with chronic kidney disease (CKD) due to glomerulonephritis (GN) are thought to be at high risk for cardiovascular disease (CVD). However, no study has examined whether GN directly contributes to CV risk beyond the effects conferred by pre-existing traditional risk factors and level of renal function. Methods: Matched cohort study using the previously described prospective CanPREDDICT study cohort. 2187 patients with CKD (eGFR 15–45 ml/min/m2) from 25 Canadian centres were divided into GN vs non-GN cause of CKD. Patients on immunotherapy for GN were not included in the study. Standardized measures of CV risk factors, biomarkers and CV outcomes were recorded over 3 years of follow-up, with the primary outcome measure being time to first all-cause CV event. Results: In the overall cohort, CV events occurred in 25 (8.7%) of the GN group and 338 (17.8%) of the non-GN group (HR 0.45, 95% CI 0.30–0.67, p 
Subject
Cardiovascular disease; Glomerulonephritis; Chronic kidney disease
Genre
Article
Type
Text
Language
eng
Date Available
2018-05-15
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0366837
URI
http://hdl.handle.net/2429/65896
Affiliation
Medicine, Faculty of; Other UBC; Non UBC; Medicine, Department of
Citation
BMC Nephrology. 2017 Mar 20;18(1):95
Publisher DOI
10.1186/s12882-017-0511-z
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)