UBC Faculty Research and Publications

Risk factors for mortality in patients admitted to intensive care units with pneumonia Li, Guowei; Cook, Deborah J; Thabane, Lehana; Friedrich, Jan O; Crozier, Tim M; Muscedere, John; Granton, John; Mehta, Sangeeta; Reynolds, Steven C; Lopes, Renato D; Francois, Lauzier; Freitag, Andreas P; Levine, Mitchell A H

Abstract

Background: Despite the high mortality in patients with pneumonia admitted to an ICU, data on risk factors for death remain limited. Methods: In this secondary analysis of PROTECT (Prophylaxis for Thromboembolism in Critical Care Trial), we focused on the patients admitted to ICU with a primary diagnosis of pneumonia. The primary outcome for this study was 90-day hospital mortality and the secondary outcome was 90-day ICU mortality. Cox regression model was conducted to examine the relationship between baseline and time-dependent variables and hospital and ICU mortality. Results: Six hundred sixty seven patients admitted with pneumonia (43.8 % females) were included in our analysis, with a mean age of 60.7 years and mean APACHE II score of 21.3. During follow-up, 111 patients (16.6 %) died in ICU and in total, 149 (22.3 %) died in hospital. Multivariable analysis demonstrated significant independent risk factors for hospital mortality including male sex (hazard ratio (HR) = 1.5, 95 % confidence interval (CI): 1.1 - 2.2, p-value = 0.021), higher APACHE II score (HR = 1.2, 95 % CI: 1.1 - 1.4, p-value 

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