UBC Faculty Research and Publications

Group B Streptococcus and Respiratory Syncytial Virus immunization during pregnancy : a landscape analysis Heath, Paul T.; Culley, Fiona J.; Jones, Christine E.; Kampmann, Beate; Le Doare, Kirsty; Nunes, Marta C.; Sadarangani, Manish; Chaudhry, Zain; Baker, Carol J.; Openshaw, Peter J.M.

Abstract

Streptococcus agalactiae or group B Streptococcus (GBS) and Respiratory Syncytial Virus (RSV) are leading causes of infant morbidity and mortality worldwide. There are currently no licensed vaccines for either disease, but vaccines for both are under development. Severe RSV disease can be prevented by passively administered antibody. The presence of maternal RSV-specific IgG antibody is associated with reduced prevalence and severity of RSV disease in the first few weeks of life, while maternal serotype-specific anti-capsular antibody is associated with protection against both early onset (EO) and late onset (LO) GBS disease. Vaccination in pregnancy offers an attractive method of protecting infants against both diseases. This structured review identifies what is known about immune protection against both diseases and identifies knowledge gaps in the immunobiology, with the aim of prioritizing research directions in maternal immunization.

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Attribution-NonCommercial-NoDerivatives 4.0 International

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