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Placental DNA methylation at term reflects maternal serum levels of INHA and FN1, but not PAPPA, early in pregnancy Wilson, Samantha L.; Blair, John D.; Hogg, Kirsten; Langlois, Sylvie; von Dadelszen, Peter; Robinson, Wendy P.

Abstract

Background: Early detection of pregnancies at risk of complications, such as intrauterine growth restriction (IUGR) and preeclampsia (PE), is critical for improved monitoring and preventative treatment to optimize health outcomes. We predict that levels of placental-derived proteins circulating in maternal blood reflect placental gene expression, which is associated with placental DNA methylation (DNAm) profiles. As such, placental DNAm profiling may be useful to distinguish pregnancies at risk of developing complications and correlation between DNAm and protein levels in maternal blood may give further evidence for a protein’s use as a biomarker. However, few studies investigate all clinical parameters that may influence DNAm and/or protein expression, which can significantly affect the relationship between these measures. Results: Candidate genes were chosen based on i) reported alterations of protein levels in maternal blood and ii) observed changes in placental DNAm (∆β > 0.05 and False Discovery Rate (FDR)

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Title
Placental DNA methylation at term reflects maternal serum levels of INHA and FN1, but not PAPPA, early in pregnancy
Creator
Wilson, Samantha L.; Blair, John D.; Hogg, Kirsten; Langlois, Sylvie; von Dadelszen, Peter; Robinson, Wendy P.
Contributor
Child and Family Research Institute
Publisher
BioMed Central
Date Issued
2015-12-11
Description
Background: Early detection of pregnancies at risk of complications, such as intrauterine growth restriction (IUGR) and preeclampsia (PE), is critical for improved monitoring and preventative treatment to optimize health outcomes. We predict that levels of placental-derived proteins circulating in maternal blood reflect placental gene expression, which is associated with placental DNA methylation (DNAm) profiles. As such, placental DNAm profiling may be useful to distinguish pregnancies at risk of developing complications and correlation between DNAm and protein levels in maternal blood may give further evidence for a protein’s use as a biomarker. However, few studies investigate all clinical parameters that may influence DNAm and/or protein expression, which can significantly affect the relationship between these measures. Results: Candidate genes were chosen based on i) reported alterations of protein levels in maternal blood and ii) observed changes in placental DNAm (∆β > 0.05 and False Discovery Rate (FDR)
Genre
Article
Type
Text
Language
eng
Date Available
2017-12-12
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0361954
URI
http://hdl.handle.net/2429/63951
Affiliation
Medicine, Faculty of; Other UBC; Non UBC; Medical Genetics, Department of; Obstetrics and Gynaecology, Department of
Citation
BMC Medical Genetics. 2015 Dec 11;16(1):111
Publisher DOI
10.1186/s12881-015-0257-z
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Wilson et al.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)