UBC Faculty Research and Publications

Association of body mass index with knee cartilage damage in an asymptomatic population-based study Keng, Alvin; Sayre, Eric C.; Guermazi, Ali; Nicolaou, Savvakis; Esdaile, John M.; Thorne, Anona; Singer, Joel; Kopeć, Jacek A.; Cibere, Jolanda


Background: Cartilage changes are an important early finding of osteoarthritis (OA), which can exist even before symptoms. Our objective was to determine the prevalence of knee cartilage damage on magnetic resonance imaging (MRI) in an asymptomatic population-based cross-sectional study and to evaluate the association of body mass index (BMI) with cartilage damage. Methods: Subjects, aged 40-79 years, without knee pain (n = 73) were recruited as a random population sample and assessed for BMI (kg/m2), including current BMI (measured), past BMI at age 25 (self-reported) and change in BMI. Knee cartilage was scored semi-quantitatively (grades 0-4) on MRI. In primary analysis, cartilage damage was defined as ≥2 (at least moderate) and in a secondary analysis as ≥3 (severe). We also conducted a sensitivity analysis by dichotomizing current BMI as

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