UBC Faculty Research and Publications

Will infant hepatitis B vaccination protect into adulthood? Extended Canadian experience after a 2, 4, 6 month immunization schedule Pinto, Michelle; Dawar, Meena; Krajden, Mel; Naus, Monika; Scheifele, David W.

Abstract

Introduction: Hepatitis B virus (HBV) vaccination programs generally target infants to prevent chronic HBV infection and/or pre-adolescents to reduce transmission in adulthood. To assess whether infant HBV immunization can potentially accomplish both objectives we measured residual immunity 10-16 years afterward in Canadian children. Methods: A prospective, parallel group, single center study enrolled adolescents given HBV vaccine at about 2, 4, 6 months of age. Exclusion criteria included prior HBV infection and additional vaccinations. At follow-up anti-HBs testing participants were 10-11 or 15-16 years old; those possibly lacking protection (

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