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Will infant hepatitis B vaccination protect into adulthood? Extended Canadian experience after a 2, 4, 6 month immunization schedule Pinto, Michelle; Dawar, Meena; Krajden, Mel; Naus, Monika; Scheifele, David W.

Abstract

Introduction: Hepatitis B virus (HBV) vaccination programs generally target infants to prevent chronic HBV infection and/or pre-adolescents to reduce transmission in adulthood. To assess whether infant HBV immunization can potentially accomplish both objectives we measured residual immunity 10-16 years afterward in Canadian children. Methods: A prospective, parallel group, single center study enrolled adolescents given HBV vaccine at about 2, 4, 6 months of age. Exclusion criteria included prior HBV infection and additional vaccinations. At follow-up anti-HBs testing participants were 10-11 or 15-16 years old; those possibly lacking protection (

Item Metadata

Title
Will infant hepatitis B vaccination protect into adulthood? Extended Canadian experience after a 2, 4, 6 month immunization schedule
Alternate Title
HBV protection 10-16 years after vaccination at 2,4,6 months; HBV protection after infant vaccination
Creator
Pinto, Michelle; Dawar, Meena; Krajden, Mel; Naus, Monika; Scheifele, David W.
Date Issued
2017-06
Description
Introduction: Hepatitis B virus (HBV) vaccination programs generally target infants to prevent chronic HBV infection and/or pre-adolescents to reduce transmission in adulthood. To assess whether infant HBV immunization can potentially accomplish both objectives we measured residual immunity 10-16 years afterward in Canadian children. Methods: A prospective, parallel group, single center study enrolled adolescents given HBV vaccine at about 2, 4, 6 months of age. Exclusion criteria included prior HBV infection and additional vaccinations. At follow-up anti-HBs testing participants were 10-11 or 15-16 years old; those possibly lacking protection (
Subject
Hepatitis B; hepatitis B vaccine; childhood immunization; immune memory; seroprotection; long-term follow-up
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2018-07-01
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0357950
URI
http://hdl.handle.net/2429/63603
Affiliation
Medicine, Faculty of; Non UBC
Citation
Pinto, M., M. Dawar, et al. (2017). “Will Infant Hepatitis B Vaccination Protect Into Adulthood?: Extended Canadian Experience After a 2-, 4-, and 6-month Immunization Schedule.” The Pediatric infectious disease journal 36(6): 609-615.
Publisher DOI
10.1097/INF.0000000000001543
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International