UBC Faculty Research and Publications

Phylogenetic clustering of hepatitis C virus among people who inject drugs in Vancouver, Canada Jacka, Brendan; Applegate, Tanya; Krajden, Mel; Olmstead, Andrea; Marshall, Brandon David Lewis; DeBeck, Kora; Milloy, M-J; Lamoury, Francois; Pybus, Oliver G.; Lima, Viviane D.; Magiorkinis, Gkikas; Montoya, Vincent Keith; Montaner, Julio; Joy, Jeffrey; Woods, Conan; Dobrer, Sabina; Dore, Gregory J.; Poon, Arthur F.; Grebely, Jason

Abstract

Little is known about factors associated with hepatitis C virus (HCV) transmission among people who inject drugs (PWID). Phylogenetic clustering and associated factors were evaluated among PWID in Vancouver, Canada. Data were derived from the Vancouver Injection Drug Users Study. Participants who were HCV antibody-positive at enrolment and those with HCV antibody seroconversion during follow-up (1996 to 2012) were tested for HCV RNA and sequenced (Core-E2 region). Phylogenetic trees were inferred using maximum likelihood analysis and clusters were identified using ClusterPicker (90% bootstrap threshold, 0.05 genetic distance threshold). Factors associated with clustering were assessed using logistic regression. Among 655 eligible participants, HCV genotype prevalence was: G1a: 48% (n=313), G1b: 6% (n=41), G2a: 3% (n=20), G2b: 7% (n=46), G3a: 33% (n=213), G4a:

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