UBC Faculty Research and Publications

Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients : A proof-of-concept RCT Warburton, D.E.R.; Campbell, K. L.; Kirkham, Amy Ashley; Shave, R. E.; Bland, K. A.; Bovard, J. M.; Eves, N. D.; Gelmon, Karen, 1953-; McKenzie, D. C.; Virani, S. A.; Stöhr, E. J.; Warburton, Darren E

Abstract

Background: Preclinical studies have reported that a single treadmill session performed 24 h prior to doxorubicin provides cardio-protection. We aimed to characterize the acute change in cardiac function following an initial doxorubicin treatment in humans and determine whether an exercise session performed 24 h prior to treatment changes this response. Methods: Breast cancer patients were randomized to either 30 minutes of vigorous-intensity exercise 24 h prior to the first doxorubicin treatment (n=13), or no vigorous exercise for 72 h prior to treatment (control, n=11). Echocardiographically-derived left ventricular volumes, longitudinal strain, twist, E/A ratio, and circulating NT-proBNP, a marker of later cardiotoxicity, were measured before and 24-48 h after the treatment. Results: Following treatment in the control group, NT-proBNP, end-diastolic and stroke volumes, cardiac output, E/A ratio, strain, diastolic strain rate, twist, and untwist velocity significantly increased (all p≤0.01). Whereas systemic vascular resistance (p

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