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Progesterone in women with arrested premature labor, a report of a randomised clinical trial and updated meta-analysis Wood, Stephen; Rabi, Yacov; Tang, Selphee; Brant, Rollin; Ross, Susan
Abstract
Background: Progesterone may be effective in prevention of premature birth in some high risk populations. Women with arrested premature labor are at risk of recurrent labor and maintenance therapy with standard tocolytics has not been successful. Methods: Randomized double blinded clinical trial of daily treatment with 200 mg vaginal progesterone in women with arrested premature labor and an updated meta-analysis. Results: The clinical trial was terminated early after 41 women were enrolled. Vaginal progesterone treatment did not change the median gestational age at delivery: 36+2 weeks versus 36+4 weeks, p = .865 nor increase the mean latency to delivery: 44.5 days versus 46.6 days, p = .841. In the updated meta-analysis, progesterone treatment did reduce delivery <37 weeks gestation and increase latency to delivery, but this treatment effect was not evident in the high quality trials: (OR 1.23, 95% CI 0.91, 1.67) and (−0.95 days, 95% CI −5.54, 3.64) respectively. Conclusion: Progesterone is not effective for preventing preterm birth following arrested preterm labor.
Item Metadata
Title |
Progesterone in women with arrested premature labor, a report of a randomised clinical trial and updated meta-analysis
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Creator | |
Publisher |
BioMed Central
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Date Issued |
2017-08-02
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Description |
Background:
Progesterone may be effective in prevention of premature birth in some high risk populations. Women with arrested premature labor are at risk of recurrent labor and maintenance therapy with standard tocolytics has not been successful.
Methods:
Randomized double blinded clinical trial of daily treatment with 200 mg vaginal progesterone in women with arrested premature labor and an updated meta-analysis.
Results:
The clinical trial was terminated early after 41 women were enrolled. Vaginal progesterone treatment did not change the median gestational age at delivery: 36+2 weeks versus 36+4 weeks, p = .865 nor increase the mean latency to delivery: 44.5 days versus 46.6 days, p = .841. In the updated meta-analysis, progesterone treatment did reduce delivery <37 weeks gestation and increase latency to delivery, but this treatment effect was not evident in the high quality trials: (OR 1.23, 95% CI 0.91, 1.67) and (−0.95 days, 95% CI −5.54, 3.64) respectively.
Conclusion:
Progesterone is not effective for preventing preterm birth following arrested preterm labor.
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Subject | |
Genre | |
Type | |
Language |
eng
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Date Available |
2017-08-08
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution 4.0 International (CC BY 4.0)
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DOI |
10.14288/1.0351984
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URI | |
Affiliation | |
Citation |
BMC Pregnancy and Childbirth. 2017 Aug 02;17(1):258
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Publisher DOI |
10.1186/s12884-017-1400-y
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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Copyright Holder |
The Author(s).
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
Attribution 4.0 International (CC BY 4.0)