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Lipoprotein (a), an independent cardiovascular risk marker Saeedi, Ramesh; Frohlich, Jiri
Abstract
Epidemiological and genetic studies have identified elevated levels of lipoprotein (a) ((Lp(a)) as a causal and independent risk factor for cardiovascular diseases (CVD). The Lp(a)-induced increased risk of CVD may be mediated by both its proatherogenic and prothrombotic mechanisms. Several guidelines recommend screening of Lp(a) level; however, there are few treatment options for the management of patients with elevated Lp(a). Several new medications for Lp(a) are under development. PCSK9 inhibitors, apolipoprotein (a)-antisense, and apolipoprotein(B-100)-antisense mipomersen have shown promising results. Lp(a) reduction will continue to be an active area of investigation.
Item Metadata
Title |
Lipoprotein (a), an independent cardiovascular risk marker
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Creator | |
Contributor | |
Publisher |
BioMed Central
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Date Issued |
2016-03-31
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Description |
Epidemiological and genetic studies have identified elevated levels of lipoprotein (a) ((Lp(a)) as a causal and independent risk factor for cardiovascular diseases (CVD). The Lp(a)-induced increased risk of CVD may be mediated by both its proatherogenic and prothrombotic mechanisms. Several guidelines recommend screening of Lp(a) level; however, there are few treatment options for the management of patients with elevated Lp(a). Several new medications for Lp(a) are under development. PCSK9 inhibitors, apolipoprotein (a)-antisense, and apolipoprotein(B-100)-antisense mipomersen have shown promising results. Lp(a) reduction will continue to be an active area of investigation.
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Subject | |
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Type | |
Language |
eng
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Date Available |
2017-05-08
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution 4.0 International (CC BY 4.0)
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DOI |
10.14288/1.0347343
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URI | |
Affiliation | |
Citation |
Clinical Diabetes and Endocrinology. 2016 Mar 31;2(1):7
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Publisher DOI |
10.1186/s40842-016-0024-x
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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Copyright Holder |
Saeedi and Frohlich.
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Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
Attribution 4.0 International (CC BY 4.0)