UBC Faculty Research and Publications

Factors associated with willingness to participate in a pharmacologic addiction treatment clinical trial among illicit drug users Uhlmann, Sasha; Milloy, M-J; Ahamad, Keith; Nguyen, Paul; Kerr, Thomas; Wood, Evan; Richardson, Lindsey

Abstract

Background and Objectives: Although new medications are needed to address the harms of drug addiction, rates of willingness to participate in addictions treatment trials among people who use drugs (PWUD) have not been well characterized. Methods: One thousand twenty PWUD enrolled in two community-recruited cohorts in Vancouver, Canada, were asked whether they would be willing to participate in an addiction treatment trial. Logistic regression was used to identify factors independently associated with a willingness to participate. Results: Among the 1,020 illicit drug users surveyed between June 1, 2013 and November 30, 2013, 58.3% indicated a willingness to participate. In multivariate analysis, factors independently associated with a willingness to participate in an addiction treatment trial, included: daily heroin injection (Adjusted Odds Ratio [AOR] = 1.75 [95% Confidence Interval [CI]: 1.13 -2.72]); daily crack smoking (AOR = 1.81 [95% CI: 1.23 – 2.66]); sex work involvement (AOR = 2.22 [95% CI: 1.21 - 4.06]); HIV seropositivity (AOR = 1.49 [95% CI: 1.15 – 1.94]); and methadone maintenance therapy participation (AOR = 1.77 [95% CI: 1.37 – 2.30]). Discussion and Conclusions: High rates of willingness to participate in an addiction treatment trial were observed in this setting. Importantly, high-risk drug and sexual activities were positively associated with a willingness to participate, which may suggest a desire for new treatment interventions among illicit drug users engaged in high-risk behaviour. Scientific Significance: These results highlight the viability of studies seeking to enroll representative samples of illicit drug users engaged in high-risk drug use.

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Attribution-NonCommercial-NoDerivatives 4.0 International

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