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Cognitive factors and willingness to participate in an HIV vaccine trial among HIV-positive injection drug users Dhalla, Shayesta; Poole, Gary; Singer, Joel; Patrick, David, (Physician); Kerr, Thomas

Abstract

There are gaps in our knowledge of the role cognitive factors play in determining people’s willingness to participate (WTP) in therapeutic HIV vaccine trials. Using a cross-sectional design in HIV-positive injection drug users (IDU), we determined the role of three cognitive factors: HIV treatment optimism, self-efficacy beliefs, and knowledge of vaccine trial concepts in relation to WTP in a hypothetical phase 3 therapeutic HIV vaccine trial. Willingness to participate was 54%. Participants tended to be low in HIV treatment optimism (mean = 3.9/10), high in self-efficacy (mean = 79.8/100), and low in knowledge (mean = 4.1/10). Items pertaining to HIV treatment optimism and knowledge of HIV vaccine trial concepts were generally unrelated to WTP. An increase in self-efficacy had a statistically significant positive association with WTP (OR = 1.61, 95% CI = 1.04–2.46, p<0.05). Furthermore, most of these HIV-positive participants had high levels of self-efficacy, so we are most confident about this relationship at such levels.

Item Metadata

Title
Cognitive factors and willingness to participate in an HIV vaccine trial among HIV-positive injection drug users
Creator
Dhalla, Shayesta; Poole, Gary; Singer, Joel; Patrick, David, (Physician); Kerr, Thomas
Contributor
British Columbia Centre for Excellence in HIV/AIDS; BC Centre for Disease Control
Date Issued
2012-01-17
Description
There are gaps in our knowledge of the role cognitive factors play in determining people’s willingness to participate (WTP) in therapeutic HIV vaccine trials. Using a cross-sectional design in HIV-positive injection drug users (IDU), we determined the role of three cognitive factors: HIV treatment optimism, self-efficacy beliefs, and knowledge of vaccine trial concepts in relation to WTP in a hypothetical phase 3 therapeutic HIV vaccine trial. Willingness to participate was 54%. Participants tended to be low in HIV treatment optimism (mean = 3.9/10), high in self-efficacy (mean = 79.8/100), and low in knowledge (mean = 4.1/10). Items pertaining to HIV treatment optimism and knowledge of HIV vaccine trial concepts were generally unrelated to WTP. An increase in self-efficacy had a statistically significant positive association with WTP (OR = 1.61, 95% CI = 1.04–2.46, p<0.05). Furthermore, most of these HIV-positive participants had high levels of self-efficacy, so we are most confident about this relationship at such levels.
Geographic Location
Downtown-Eastside (Vancouver, B.C.)
Genre
Article
Type
Text
Language
eng
Date Available
2017-01-21
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0340703
URI
http://hdl.handle.net/2429/60314
Affiliation
Medicine, Faculty of; Other UBC; Non UBC; Medicine, Department of; Population and Public Health (SPPH), School of
Citation
Dhalla, S., Poole, G., Singer, J., Patrick, D. M., & Kerr, T. (2012). Cognitive factors and willingness to participate in an HIV vaccine trial among HIV-positive injection drug users. Psychology, Health & Medicine, 17(2), 223–234
Publisher DOI
10.1080/13548506.2011.608803
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International