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Reinfection with hepatitis C virus following sustained virological response in injection drug users Grebely, Jason; Knight, Elizabeth; Ngai, Tyler; Genoway, Krista; Raffa, Jesse Daniel; Storms, Michelle; Gallagher, Lesley; Krajden, Mel; Dore, Gregory J.; Duncan, Fiona; Conway, Brian
Abstract
Background and Aim: Despite that 60–90% of injection drug users (IDUs) are infected with hepatitis C virus (HCV) infection, IDUs are often denied therapy based on concerns of reinfection following treatment. However, there are little data in this regard. We evaluated HCV re-infection following sustained virologic response (SVR) among HCV-infected IDUs having received HCV treatment in a multidisciplinary program. Methods: Following treatment, participants were encouraged to return at follow-up intervals of 1 year and illicit drug use histories were obtained. In those with SVR, HCV RNA testing by PCR was performed to determine if relapse or reinfection occurred. Results: Among 58 receiving HCV treatment between January 2002 and December 2006, 60% (35 of 58) achieved an SVR. Patients were followed for a median of 2.0 years following SVR (range, 0.4–5.0 years), with ongoing illicit and injection drug use reported in 54% (19 of 35) and 46% (16 of 35). Of the 35 with SVR, 28 remained HCV RNA negative during follow-up (80%), with four lost to follow-up and one dying of hepatocellular carcinoma and two cases of reinfection were observed (2 of 35). The rates of reinfection were 3.2 per 100 p-y (95% CI:0.4, 11.5) overall and 5.3 per 100 p-y (95% CI:0.6, 19.0) among those reporting injecting following SVR (n = 16). One of two participants with HCV re-infection spontaneously cleared virus following reinfection. Conclusion: The rate of reinfection following treatment for HCV infection among current and former IDUs engaged in a multidisciplinary program is low.
Item Metadata
| Title |
Reinfection with hepatitis C virus following sustained virological response in injection drug users
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| Alternate Title |
HCV reinfection following SVR in IDUs
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| Creator | |
| Contributor | |
| Date Issued |
2010-06-23
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| Description |
Background and Aim: Despite that 60–90% of injection drug users (IDUs) are infected with hepatitis C virus (HCV) infection, IDUs are often denied therapy based on concerns of reinfection following treatment. However, there are little data in this regard. We evaluated HCV re-infection following sustained virologic response (SVR) among HCV-infected IDUs having received HCV treatment in a multidisciplinary program.
Methods: Following treatment, participants were encouraged to return at follow-up intervals of 1 year and illicit drug use histories were obtained. In those with SVR, HCV RNA testing by PCR was performed to determine if relapse or reinfection occurred.
Results: Among 58 receiving HCV treatment between January 2002 and December 2006, 60% (35 of 58) achieved an SVR. Patients were followed for a median of 2.0 years following SVR (range, 0.4–5.0 years), with ongoing illicit and injection drug use reported in 54% (19 of 35) and 46% (16 of 35). Of the 35 with SVR, 28 remained HCV RNA negative during follow-up (80%), with four lost to follow-up and one dying of hepatocellular carcinoma and two cases of reinfection were observed (2 of 35). The rates of reinfection were 3.2 per 100 p-y (95% CI:0.4, 11.5) overall and 5.3 per 100 p-y (95% CI:0.6, 19.0) among those reporting injecting following SVR (n = 16). One of two participants with HCV re-infection spontaneously cleared virus following reinfection.
Conclusion: The rate of reinfection following treatment for HCV infection among current and former IDUs engaged in a multidisciplinary program is low.
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| Subject | |
| Geographic Location | |
| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2017-01-21
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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| DOI |
10.14288/1.0339811
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| URI | |
| Affiliation | |
| Citation |
Grebely J, Knight E, Ngai T, Genoway KA, Raffa JD, Storms M, Gallagher L, Krajden M, Dore GJ, Duncan F, Conway B. Reinfection with hepatitis C virus following sustained virological response in injection drug users. J Gastroenterol Hepatol. 2010 Jul;25(7):1281-4.
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| Publisher DOI |
10.1111/j.1440-1746.2010.06238
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| Peer Review Status |
Reviewed
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| Scholarly Level |
Faculty; Researcher; Graduate
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| Copyright Holder |
Jason Grebely
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution-NonCommercial-NoDerivatives 4.0 International