Molecularly Defined Adult Granulosa Cell Tumor of the Ovary : the clinical phenotype McConechy, Melissa K.; Färkkilä, Anniina; Horlings, Hugo M.; Talhouk, Aline; Unkila-Kallio, Leila; van Meurs, Hannah S.; Yang, Winnie; Rozenberg, Nirit; Andersson, Noora; Zaby, Katharina; Bryk, Saara; Bützow, Ralf; Kommoss, Friedrich; Halfwerk, Johannes B.G.; Hooijer, Gerrit K.J.; van de Vijver, Marc J.; Buist, Marrije R.; Kenter, Gemma G.; Brucker, Sara Y.; Kraemer, Bernhard; Staebler, Annette; Bleeker, Maaike C.G.; Heikinheimo, Markku; Kommoss, Stefan; Gilks, C. Blake; Anttonen, Mikko; Huntsman, David G.
The histopathologic features of Adult Granulosa Cell Tumors (AGCTs) are relatively non-specific, resulting in misdiagnosis of other cancers as AGCT, a problem that has not been well characterized. FOXL2 mutation testing was used to stratify 336 AGCTs from three European centers into three categories: 1) FOXL2 mutant molecularly defined AGCT (MD-AGCT)(n=256 of 336), 2) FOXL2 wild-type AGCT (n=17 of 336), 3) misdiagnosed other tumor types (n=63 of 336). All statistical tests were two-sided. The overall and disease-specific survival of the misdiagnosed cases was lower than in the MD-AGCTs (P
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