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Understanding Neonatal Sepsis at the Molecular Immunological Level Kan, Bernard; Razzaghian, Hamid; Lavoie, Pascal M.

Abstract

Despite concerted international efforts, mortality from neonatal infections remains unacceptably high in some areas of the world, particularly for premature infants. Recent developments in flow cytometry and next-generation sequencing technologies have led to major discoveries over the past few years, providing a more integrated understanding of the developing human immune system in the context of its microbial environment. We review these recent findings, focusing on how in human newborns incomplete maturation of the immune system before a full term of gestation impacts on their vulnerability to infection. We also discuss some of the clinical implications of this research in guiding the design of more-accurate age-adapted diagnostic and preventive strategies for neonatal sepsis.

Item Metadata

Title
Understanding Neonatal Sepsis at the Molecular Immunological Level
Creator
Kan, Bernard; Razzaghian, Hamid; Lavoie, Pascal M.
Contributor
Child and Family Research Institute
Date Issued
2016
Description
Despite concerted international efforts, mortality from neonatal infections remains unacceptably high in some areas of the world, particularly for premature infants. Recent developments in flow cytometry and next-generation sequencing technologies have led to major discoveries over the past few years, providing a more integrated understanding of the developing human immune system in the context of its microbial environment. We review these recent findings, focusing on how in human newborns incomplete maturation of the immune system before a full term of gestation impacts on their vulnerability to infection. We also discuss some of the clinical implications of this research in guiding the design of more-accurate age-adapted diagnostic and preventive strategies for neonatal sepsis.
Subject
Neonate; Immunology; Systems Biology; Ontogeny; Fetal development
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2017-04-01
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0314573
URI
http://hdl.handle.net/2429/59253
Affiliation
Medicine, Faculty of; Other UBC; Pediatrics, Department of; Medicine, Department of
Citation
Kan B, Razzaghian HR, Lavoie PM. An immunological perspective on neonatal sepsis. Trends in Molecular Medicine. 2016;22(4):290-302.
Publisher DOI
10.1016/j.molmed.2016.02.001.
Peer Review Status
Reviewed
Scholarly Level
Faculty; Postdoctoral; Graduate
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
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Attribution-NonCommercial-NoDerivatives 4.0 International