Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection

UBC Faculty Research and Publications

Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection Burgess, Thomas S.T.; Hirschfeld, Aaron F.; Tyrrell, Gregory J.; Bettinger, Julie A.; Turvey, Stuart E.

Abstract

Although there are more than 90 serotypes of Streptococcus pneumoniae (or pneumococcus), it is not understood why a small number of serotypes account for most invasive infections. To investigate the human innate immune response triggered by different pneumococcal serotypes, monocyte-derived macrophages were exposed to a group of commonly and rarely invasive pneumococcal clinical isolates and tumor necrosis factor (TNF)-α production was measured. Commonly invasive pneumococcal serotypes triggered significantly less TNF-α production than serotypes rarely responsible for invasive infection (P < 0.004). These data indicate that one factor influencing the invasive potential of a pneumococcal serotype is the magnitude of innate immune-mediated TNF-α production triggered by exposure to the organism and suggest that the integrated host response generated against commonly invasive pneumococcal serotypes may be less effective than the response directed against rarely invasive serotypes.

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Title	Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection
Creator	Burgess, Thomas S.T.; Hirschfeld, Aaron F.; Tyrrell, Gregory J.; Bettinger, Julie A.; Turvey, Stuart E.
Date Issued	2007
Description	Although there are more than 90 serotypes of Streptococcus pneumoniae (or pneumococcus), it is not understood why a small number of serotypes account for most invasive infections. To investigate the human innate immune response triggered by different pneumococcal serotypes, monocyte-derived macrophages were exposed to a group of commonly and rarely invasive pneumococcal clinical isolates and tumor necrosis factor (TNF)-α production was measured. Commonly invasive pneumococcal serotypes triggered significantly less TNF-α production than serotypes rarely responsible for invasive infection (P < 0.004). These data indicate that one factor influencing the invasive potential of a pneumococcal serotype is the magnitude of innate immune-mediated TNF-α production triggered by exposure to the organism and suggest that the integrated host response generated against commonly invasive pneumococcal serotypes may be less effective than the response directed against rarely invasive serotypes.
Subject	Streptococcus pneumoniae; pneumococcus; innate immunity
Genre	Article
Type	Text
Language	eng
Date Available	2016-03-15
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivs 2.5 Canada
DOI	10.14288/1.0228200
URI	http://hdl.handle.net/2429/57178
Affiliation	Medicine, Department of; Medicine, Faculty of; Pediatrics, Department of; Non UBC
Citation	Burgess, T. S. T., Hirschfeld, A. F., Tyrrell, G. J., Bettinger, J. A., & Turvey, S. E. (2008). Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection. FEMS Immunology and Medical Microbiology, 53(1), 136-139.
Publisher DOI	10.1111/j.1574-695X.2008.00382.x
Peer Review Status	Reviewed
Scholarly Level	Faculty
Rights URI	http://creativecommons.org/licenses/by-nc-nd/2.5/ca/
Aggregated Source Repository	DSpace

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