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The functional role of long non-coding RNA in human carcinomas Gibb, Ewan A.; Brown, Carolyn Janet; Lam, Wan

Abstract

Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.

Item Metadata

Title
The functional role of long non-coding RNA in human carcinomas
Creator
Gibb, Ewan A.; Brown, Carolyn Janet; Lam, Wan
Publisher
BioMed Central
Date Issued
2011-04-13
Description
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.
Genre
Article
Type
Text
Language
eng
Date Available
2016-02-10
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0224074
URI
http://hdl.handle.net/2429/56959
Affiliation
Medical Genetics, Department of; Medicine, Faculty of; Pathology and Laboratory Medicine, Department of; Non UBC
Citation
Molecular Cancer. 2011 Apr 13;10(1):38
Publisher DOI
10.1186/1476-4598-10-38
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Gibb et al; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)