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2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema Bowen, Tom; Cicardi, Marco; Farkas, Henriette; Bork, Konrad; Longhurst, Hilary J; Zuraw, Bruce; Aygoeren-Pürsün, Emel; Craig, Timothy; Binkley, Karen; Hebert, Jacques; Ritchie, Bruce; Bouillet, Laurence; Betschel, Stephen; Cogar, Della; Dean, John; Devaraj, Ramachand; Hamed, Azza; Kamra, Palinder; Keith, Paul K; Lacuesta, Gina; Leith, Eric; Lyons, Harriet; Mace, Sean; Mako, Barbara; Neurath, Doris; Poon, Man-Chiu; Rivard, Georges-Etienne; Schellenberg, Robert; Rowan, Dereth; Rowe, Anne; Stark, Donald; Sur, Smeeksha; Tsai, Ellie; Warrington, Richard; Waserman, Susan; Ameratunga, Rohan; Bernstein, Jonathan; Björkander, Janne; Brosz, Kristylea; Brosz, John; Bygum, Anette; Caballero, Teresa; Frank, Mike; Fust, George; Harmat, George; Kanani, Amin; Kreuz, Wolfhart; Levi, Marcel; Li, Henry; Martinez-Saguer, Inmaculada; Moldovan, Dumitru; Nagy, Istvan; Nielsen, Erik W; Nordenfelt, Patrik; Reshef, Avner; Rusicke, Eva; Smith-Foltz, Sarah; Späth, Peter; Varga, Lilian; Yu Xiang, Zhi

Abstract

Background: We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Objective: To update the International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema (circa 2010). Methods: The Canadian Hereditary Angioedema Network (CHAEN)/Réseau Canadien d'angioédème héréditaire (RCAH) http://www.haecanada.com and cosponsors University of Calgary and the Canadian Society of Allergy and Clinical Immunology (with an unrestricted educational grant from CSL Behring) held our third Conference May 15th to 16th, 2010 in Toronto Canada to update our consensus approach. The Consensus document was reviewed at the meeting and then circulated for review. Results: This manuscript is the 2010 International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema that resulted from that conference. Conclusions: Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches including quality of life and cost benefit analyses, followed by large head-to-head clinical trials and then evidence-based guidelines and standards for HAE disease management.

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Title
2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
Creator
Bowen, Tom; Cicardi, Marco; Farkas, Henriette; Bork, Konrad; Longhurst, Hilary J; Zuraw, Bruce; Aygoeren-Pürsün, Emel; Craig, Timothy; Binkley, Karen; Hebert, Jacques; Ritchie, Bruce; Bouillet, Laurence; Betschel, Stephen; Cogar, Della; Dean, John; Devaraj, Ramachand; Hamed, Azza; Kamra, Palinder; Keith, Paul K; Lacuesta, Gina; Leith, Eric; Lyons, Harriet; Mace, Sean; Mako, Barbara; Neurath, Doris; Poon, Man-Chiu; Rivard, Georges-Etienne; Schellenberg, Robert; Rowan, Dereth; Rowe, Anne; Stark, Donald; Sur, Smeeksha; Tsai, Ellie; Warrington, Richard; Waserman, Susan; Ameratunga, Rohan; Bernstein, Jonathan; Björkander, Janne; Brosz, Kristylea; Brosz, John; Bygum, Anette; Caballero, Teresa; Frank, Mike; Fust, George; Harmat, George; Kanani, Amin; Kreuz, Wolfhart; Levi, Marcel; Li, Henry; Martinez-Saguer, Inmaculada; Moldovan, Dumitru; Nagy, Istvan; Nielsen, Erik W; Nordenfelt, Patrik; Reshef, Avner; Rusicke, Eva; Smith-Foltz, Sarah; Späth, Peter; Varga, Lilian; Yu Xiang, Zhi
Publisher
BioMed Central
Date Issued
2010-07-28
Description
Background: We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Objective: To update the International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema (circa 2010). Methods: The Canadian Hereditary Angioedema Network (CHAEN)/Réseau Canadien d'angioédème héréditaire (RCAH) http://www.haecanada.com and cosponsors University of Calgary and the Canadian Society of Allergy and Clinical Immunology (with an unrestricted educational grant from CSL Behring) held our third Conference May 15th to 16th, 2010 in Toronto Canada to update our consensus approach. The Consensus document was reviewed at the meeting and then circulated for review. Results: This manuscript is the 2010 International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema that resulted from that conference. Conclusions: Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches including quality of life and cost benefit analyses, followed by large head-to-head clinical trials and then evidence-based guidelines and standards for HAE disease management.
Genre
Article
Type
Text
Language
eng
Date Available
2016-02-10
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0224073
URI
http://hdl.handle.net/2429/56961
Affiliation
Medicine, Department of; Medicine, Faculty of; Pediatrics, Department of; Non UBC
Citation
Allergy, Asthma & Clinical Immunology. 2010 Jul 28;6(1):24
Publisher DOI
10.1186/1710-1492-6-24
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Bowen et al.
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)