Open Collections

UBC Faculty Research and Publications

Poor balance and lower gray matter volume predict falls in older adults with mild cognitive impairment Makizako, Hyuma; Shimada, Hiroyuki; Doi, Takehiko; Park, Hyuntae; Yoshida, Daisuke; Uemura, Kazuki; Tsutsumimoto, Kota; Liu-Ambrose, Teresa; Suzuki, Takao

Abstract

Background: The risk of falling is associated with cognitive dysfunction. Older adults with mild cognitive impairment (MCI) exhibit an accelerated reduction of brain volume, and face an increased risk of falling. The current study examined the relationship between baseline physical performance, baseline gray matter volume and falls during a 12-month follow-up period among community-dwelling older adults with MCI. Methods: Forty-two older adults with MCI (75.6 years, 43% women) underwent structural magnetic resonance imaging and baseline physical performance assessment, including knee-extension strength, one-legged standing time, and walking speed with normal pace. ‘Fallers’ were defined as people who had one or more falls during the 12-month follow-up period. Results: Of the 42 participants, 26.2% (n = 11) experienced at least one fall during the 12-month follow-up period. Fallers exhibited slower walking speed and shorter one-legged standing time compared with non-fallers (both p 

Item Metadata

Title
Poor balance and lower gray matter volume predict falls in older adults with mild cognitive impairment
Creator
Makizako, Hyuma; Shimada, Hiroyuki; Doi, Takehiko; Park, Hyuntae; Yoshida, Daisuke; Uemura, Kazuki; Tsutsumimoto, Kota; Liu-Ambrose, Teresa; Suzuki, Takao
Contributor
University of British Columbia. Djavad Mowafaghian Centre for Brain Health
Publisher
BioMed Central
Date Issued
2013-08-05
Description
Background: The risk of falling is associated with cognitive dysfunction. Older adults with mild cognitive impairment (MCI) exhibit an accelerated reduction of brain volume, and face an increased risk of falling. The current study examined the relationship between baseline physical performance, baseline gray matter volume and falls during a 12-month follow-up period among community-dwelling older adults with MCI. Methods: Forty-two older adults with MCI (75.6 years, 43% women) underwent structural magnetic resonance imaging and baseline physical performance assessment, including knee-extension strength, one-legged standing time, and walking speed with normal pace. ‘Fallers’ were defined as people who had one or more falls during the 12-month follow-up period. Results: Of the 42 participants, 26.2% (n = 11) experienced at least one fall during the 12-month follow-up period. Fallers exhibited slower walking speed and shorter one-legged standing time compared with non-fallers (both p 
Genre
Article
Type
Text
Language
eng
Date Available
2016-01-28
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0223849
URI
http://hdl.handle.net/2429/56782
Affiliation
Physical Therapy, Department of; Other UBC; Non UBC; Medicine, Faculty of
Citation
BMC Neurology. 2013 Aug 05;13(1):102
Publisher DOI
10.1186/1471-2377-13-102
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Makizako et al.; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

Item Media

Item Citations and Data

Rights

Attribution 4.0 International (CC BY 4.0)