UBC Faculty Research and Publications

Poor balance and lower gray matter volume predict falls in older adults with mild cognitive impairment Makizako, Hyuma; Shimada, Hiroyuki; Doi, Takehiko; Park, Hyuntae; Yoshida, Daisuke; Uemura, Kazuki; Tsutsumimoto, Kota; Liu-Ambrose, Teresa; Suzuki, Takao


Background: The risk of falling is associated with cognitive dysfunction. Older adults with mild cognitive impairment (MCI) exhibit an accelerated reduction of brain volume, and face an increased risk of falling. The current study examined the relationship between baseline physical performance, baseline gray matter volume and falls during a 12-month follow-up period among community-dwelling older adults with MCI. Methods: Forty-two older adults with MCI (75.6 years, 43% women) underwent structural magnetic resonance imaging and baseline physical performance assessment, including knee-extension strength, one-legged standing time, and walking speed with normal pace. ‘Fallers’ were defined as people who had one or more falls during the 12-month follow-up period. Results: Of the 42 participants, 26.2% (n = 11) experienced at least one fall during the 12-month follow-up period. Fallers exhibited slower walking speed and shorter one-legged standing time compared with non-fallers (both p 

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