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Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon Dirks, Rachel C; Richard, Jeffrey S; Fearon, Angela M; Scott, Alexander; Koch, Lauren G; Britton, Steven L; Warden, Stuart J
Abstract
Background: The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans. Methods: Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis. Results: There were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14). Conclusions: Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.
Item Metadata
Title |
Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon
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Creator | |
Publisher |
BioMed Central
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Date Issued |
2013-03-11
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Description |
Background:
The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.
Methods:
Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis.
Results:
There were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14).
Conclusions:
Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.
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Subject | |
Genre | |
Type | |
Language |
eng
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Date Available |
2016-01-27
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution 4.0 International (CC BY 4.0)
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DOI |
10.14288/1.0223793
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URI | |
Affiliation | |
Citation |
BMC Musculoskeletal Disorders. 2013 Mar 11;14(1):90
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Publisher DOI |
10.1186/1471-2474-14-90
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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Copyright Holder |
Dirks et al; licensee BioMed Central Ltd.
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
Attribution 4.0 International (CC BY 4.0)