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Clinical usefulness of lipid ratios to identify men and women with metabolic syndrome: a cross-sectional study Gasevic, Danijela; Frohlich, Jiri; Mancini, GB J.; Lear, Scott A.

Abstract

Background: Waist circumference, a metabolic syndrome (MetSy) criterion, is not routinely measured in clinical practice making early identification of individuals with MetSy challenging. It has been argued that ratios of commonly measured parameters such as lipids and lipoproteins may be an acceptable alternative for identifying individuals with MetSy. The objective of our study was to explore clinical utility of lipid ratios to identify men and women with MetSy; and to explore the association between lipid ratios and the number of MetSy components. Methods Men and women (N = 797) of Aboriginal, Chinese, European, and South Asian origin (35–60 years), recruited across ranges of body mass index (BMI), with no diagnosed cardiovascular disease (CVD) or on medications to treat CVD risk factors were assessed for anthropometrics, family history of CVD, MetSy components (waist circumference, blood pressure, glucose, triglycerides (TG), high-density-lipoprotein-cholesterol (HDL-C)), low-density-lipoprotein-cholesterol (LDL-C), nonHDL-C, and health-related behaviours. Results Mean levels of lipid ratios significantly increased with increasing number of MetSy components in men and women (p 

Item Metadata

Title
Clinical usefulness of lipid ratios to identify men and women with metabolic syndrome: a cross-sectional study
Creator
Gasevic, Danijela; Frohlich, Jiri; Mancini, GB J.; Lear, Scott A.
Publisher
BioMed Central
Date Issued
2014-10-10
Description
Background: Waist circumference, a metabolic syndrome (MetSy) criterion, is not routinely measured in clinical practice making early identification of individuals with MetSy challenging. It has been argued that ratios of commonly measured parameters such as lipids and lipoproteins may be an acceptable alternative for identifying individuals with MetSy. The objective of our study was to explore clinical utility of lipid ratios to identify men and women with MetSy; and to explore the association between lipid ratios and the number of MetSy components. Methods Men and women (N = 797) of Aboriginal, Chinese, European, and South Asian origin (35–60 years), recruited across ranges of body mass index (BMI), with no diagnosed cardiovascular disease (CVD) or on medications to treat CVD risk factors were assessed for anthropometrics, family history of CVD, MetSy components (waist circumference, blood pressure, glucose, triglycerides (TG), high-density-lipoprotein-cholesterol (HDL-C)), low-density-lipoprotein-cholesterol (LDL-C), nonHDL-C, and health-related behaviours. Results Mean levels of lipid ratios significantly increased with increasing number of MetSy components in men and women (p 
Subject
Metabolic syndrome; Lipid ratios; Triglyceride-to-high-density-lipoprotein-cholesterol; Low-densitylipoprotein- cholesterol-to-high-density-lipoprotein-cholesterol; Non-high-density-lipoprotein-cholesterol-to-highdensity- lipoprotein-cholesterol; total cholesterol-to-high-density-lipoprotein-cholesterol
Genre
Article
Type
Text
Language
eng
Date Available
2015-12-24
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0223727
URI
http://hdl.handle.net/2429/56070
Affiliation
Medicine, Department of; Medicine, Faculty of; Pathology and Laboratory Medicine, Department of; Non UBC
Citation
Lipids in Health and Disease. 2014 Oct 10;13(1):159
Publisher DOI
10.1186/1476-511X-13-159
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Gasevic et al.; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)