Clinical usefulness of lipid ratios to identify men and women with metabolic syndrome: a cross-sectional study

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Clinical usefulness of lipid ratios to identify men and women with metabolic syndrome: a cross-sectional study Gasevic, Danijela; Frohlich, Jiri; Mancini, GB J; Lear, Scott A

Abstract

Background: Waist circumference, a metabolic syndrome (MetSy) criterion, is not routinely measured in clinical practice making early identification of individuals with MetSy challenging. It has been argued that ratios of commonly measured parameters such as lipids and lipoproteins may be an acceptable alternative for identifying individuals with MetSy. The objective of our study was to explore clinical utility of lipid ratios to identify men and women with MetSy; and to explore the association between lipid ratios and the number of MetSy components. Methods Men and women (N = 797) of Aboriginal, Chinese, European, and South Asian origin (35–60 years), recruited across ranges of body mass index (BMI), with no diagnosed cardiovascular disease (CVD) or on medications to treat CVD risk factors were assessed for anthropometrics, family history of CVD, MetSy components (waist circumference, blood pressure, glucose, triglycerides (TG), high-density-lipoprotein-cholesterol (HDL-C)), low-density-lipoprotein-cholesterol (LDL-C), nonHDL-C, and health-related behaviours. Results Mean levels of lipid ratios significantly increased with increasing number of MetSy components in men and women (p

Item Metadata

Title	Clinical usefulness of lipid ratios to identify men and women with metabolic syndrome: a cross-sectional study
Creator	Gasevic, Danijela; Frohlich, Jiri; Mancini, GB J; Lear, Scott A
Publisher	BioMed Central
Date Issued	2014-10-10
Description	Background: Waist circumference, a metabolic syndrome (MetSy) criterion, is not routinely measured in clinical practice making early identification of individuals with MetSy challenging. It has been argued that ratios of commonly measured parameters such as lipids and lipoproteins may be an acceptable alternative for identifying individuals with MetSy. The objective of our study was to explore clinical utility of lipid ratios to identify men and women with MetSy; and to explore the association between lipid ratios and the number of MetSy components. Methods Men and women (N = 797) of Aboriginal, Chinese, European, and South Asian origin (35–60 years), recruited across ranges of body mass index (BMI), with no diagnosed cardiovascular disease (CVD) or on medications to treat CVD risk factors were assessed for anthropometrics, family history of CVD, MetSy components (waist circumference, blood pressure, glucose, triglycerides (TG), high-density-lipoprotein-cholesterol (HDL-C)), low-density-lipoprotein-cholesterol (LDL-C), nonHDL-C, and health-related behaviours. Results Mean levels of lipid ratios significantly increased with increasing number of MetSy components in men and women (p
Subject	Metabolic syndrome; Lipid ratios; Triglyceride-to-high-density-lipoprotein-cholesterol; Low-densitylipoprotein- cholesterol-to-high-density-lipoprotein-cholesterol; Non-high-density-lipoprotein-cholesterol-to-highdensity- lipoprotein-cholesterol; total cholesterol-to-high-density-lipoprotein-cholesterol
Genre	Article
Type	Text
Language	eng
Date Available	2015-12-24
Provider	Vancouver : University of British Columbia Library
Rights	Attribution 4.0 International (CC BY 4.0)
DOI	10.14288/1.0223727
URI	http://hdl.handle.net/2429/56070
Affiliation	Medicine, Department of; Medicine, Faculty of; Pathology and Laboratory Medicine, Department of; Non UBC
Citation	Lipids in Health and Disease. 2014 Oct 10;13(1):159
Publisher DOI	10.1186/1476-511X-13-159
Peer Review Status	Reviewed
Scholarly Level	Faculty
Copyright Holder	Gasevic et al.; licensee BioMed Central Ltd.
Rights URI	http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository	DSpace

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