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Myxoid liposarcoma in a 91-year-old patient Sheffield, Brandon S.; Nielsen, Torsten

Abstract

Background: Myxoid liposarcoma is a mesenchymal malignancy most commonly presenting in young adults. This tumor is known for its characteristic chromosomal rearrangement at the DDIT3 locus. Results: We report a case of myxoid liposarcoma in a 91-year-old, the oldest known patient with this disease-entity. FISH analysis of the DDIT3 and FUS loci demonstrate the pathognomonic chromosomal alteration in the setting of predominantly round cell histology on biopsy, confirmed by RT-PCR. Conclusion: Myxoid liposarcoma affects mostly young adults but can be seen in the elderly population. Molecular and cytogenetic assays are helpful auxiliaries to histology in the setting of unusual histology and clinical presentation.

Item Metadata

Title
Myxoid liposarcoma in a 91-year-old patient
Creator
Sheffield, Brandon S.; Nielsen, Torsten
Publisher
BioMed Central
Date Issued
2013-11-19
Description
Background: Myxoid liposarcoma is a mesenchymal malignancy most commonly presenting in young adults. This tumor is known for its characteristic chromosomal rearrangement at the DDIT3 locus. Results: We report a case of myxoid liposarcoma in a 91-year-old, the oldest known patient with this disease-entity. FISH analysis of the DDIT3 and FUS loci demonstrate the pathognomonic chromosomal alteration in the setting of predominantly round cell histology on biopsy, confirmed by RT-PCR. Conclusion: Myxoid liposarcoma affects mostly young adults but can be seen in the elderly population. Molecular and cytogenetic assays are helpful auxiliaries to histology in the setting of unusual histology and clinical presentation.
Subject
Liposarcoma; Myxoid liposarcoma; Round cell liposarcoma; Advanced age; DDIT3; FUS; FISH
Genre
Article
Type
Text
Language
eng
Date Available
2016-01-13
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0223306
URI
http://hdl.handle.net/2429/56427
Affiliation
Medicine, Faculty of; Pathology and Laboratory Medicine, Department of
Citation
Molecular Cytogenetics. 2013 Nov 19;6(1):50
Publisher DOI
10.1186/1755-8166-6-50
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Sheffield and Nielsen; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
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Attribution 4.0 International (CC BY 4.0)