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Metabolic changes in cardiomyocytes during sepsis Douglas, James J.; Walley, Keith R. (Keith Robert)
Abstract
Different types of shock induce distinct metabolic changes. The myocardium at rest utilizes free fatty acids as its primary energy source, a mechanism that changes to aerobic glycolysis during sepsis and is in contrast to hemorrhagic shock. The immune system also uses this mechanism, changing its substrate utilization to activate innate and adaptive cells. Cardiomyocytes share a number of features similar to antigen-presenting cells and may use this mechanism to augment the immune response at the reversible expense of cardiac function.
Item Metadata
| Title |
Metabolic changes in cardiomyocytes during sepsis
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| Creator | |
| Publisher |
BioMed Central
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| Date Issued |
2013-09-20
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| Description |
Different types of shock induce distinct metabolic changes. The myocardium at rest utilizes free fatty acids as its primary energy source, a mechanism that changes to aerobic glycolysis during sepsis and is in contrast to hemorrhagic shock. The immune system also uses this mechanism, changing its substrate utilization to activate innate and adaptive cells. Cardiomyocytes share a number of features similar to antigen-presenting cells and may use this mechanism to augment the immune response at the reversible expense of cardiac function.
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| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2016-01-05
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution 4.0 International (CC BY 4.0)
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| DOI |
10.14288/1.0223053
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| URI | |
| Affiliation | |
| Citation |
Critical Care. 2013 Sep 20;17(5):186
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| Publisher DOI |
10.1186/1364-8535-17-186
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| Peer Review Status |
Reviewed
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| Scholarly Level |
Faculty
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| Copyright Holder |
BioMed Central Ltd.
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Rights
Attribution 4.0 International (CC BY 4.0)