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Putting the pH into phosphatidic acid signaling Shin, John J; Loewen, Christopher J
Abstract
Abstract: The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.
Item Metadata
Title |
Putting the pH into phosphatidic acid signaling
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Creator | |
Contributor | |
Publisher |
BioMed Central
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Date Issued |
2011-12-02
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Description |
Abstract:
The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.
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Genre | |
Type | |
Language |
eng
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Date Available |
2015-12-16
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution 4.0 International (CC BY 4.0)
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DOI |
10.14288/1.0221315
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URI | |
Affiliation | |
Citation |
BMC Biology. 2011 Dec 02;9(1):85
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Publisher DOI |
10.1186/1741-7007-9-85
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Peer Review Status |
Reviewed
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Scholarly Level |
Faculty
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Copyright Holder |
Shin and Loewen; licensee BioMed Central Ltd.
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Citations and Data
Rights
Attribution 4.0 International (CC BY 4.0)