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Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain Wickham, Mark E.; Brown, Nat F.; Provias, John; Finlay, B. Brett, 1959-; Coombes, Brian K.

Abstract

Background. Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain. Methods Five mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1 Mcg , 129S1/SvImJ, B6.129-Inpp5dtm1 Rkh were used in the murine typhoid model to examine the dissemination of systemic Salmonella enterica serovar Typhimurium following oral infection. Results We report data on spontaneous meningitis and brain infection following oral infection of mice with Salmonella enterica serovar Typhimurium. Conclusion This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried.

Item Metadata

Title
Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
Creator
Wickham, Mark E.; Brown, Nat F.; Provias, John; Finlay, B. Brett, 1959-; Coombes, Brian K.
Contributor
Michael Smith Laboratories
Publisher
BioMed Central
Date Issued
2007-06-27
Description
Background. Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain. Methods Five mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1 Mcg , 129S1/SvImJ, B6.129-Inpp5dtm1 Rkh were used in the murine typhoid model to examine the dissemination of systemic Salmonella enterica serovar Typhimurium following oral infection. Results We report data on spontaneous meningitis and brain infection following oral infection of mice with Salmonella enterica serovar Typhimurium. Conclusion This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried.
Genre
Article
Type
Text
Language
eng
Date Available
2015-10-24
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0220705
URI
http://hdl.handle.net/2429/54773
Affiliation
Non UBC; Science, Faculty of; Microbiology and Immunology, Department of
Citation
BMC Infectious Diseases. 2007 Jun 27;7(1):65
Publisher DOI
10.1186/1471-2334-7-65
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Wickham et al.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)