UBC Faculty Research and Publications

Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain Wickham, Mark E; Brown, Nat F; Provias, John; Finlay, B B; Coombes, Brian K

Abstract

Background. Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain. Methods Five mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1 Mcg , 129S1/SvImJ, B6.129-Inpp5dtm1 Rkh were used in the murine typhoid model to examine the dissemination of systemic Salmonella enterica serovar Typhimurium following oral infection. Results We report data on spontaneous meningitis and brain infection following oral infection of mice with Salmonella enterica serovar Typhimurium. Conclusion This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried.

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Attribution 4.0 International (CC BY 4.0)