UBC Faculty Research and Publications

Polymeric nanocarriers for the treatment of systemic iron overload Hamilton, Jasmine L; Kizhakkedathu, Jayachandran N


Desferrioxamine (DFO), deferiprone (L1) and desferasirox (ICL-670) are clinically approved iron chelators used to treat secondary iron overload. Although iron chelators have been utilized since the 1960s and there has been much improvement in available therapy, there is still the need for new drug candidates due to limited long-term efficacy and drug toxicity. Moreover, all currently approved iron chelators are of low molecular weight (MW) (

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