- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- UBC Faculty Research and Publications /
- Submaximal exercise testing with near-infrared spectroscopy...
Open Collections
UBC Faculty Research and Publications
Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: a case–control study Miller, Ruth R.; Reid, W. D.; Mattman, Andre; Yamabayashi, Cristiane; Steiner, Theodore S.; Parker, Shoshana; Gardy, Jennifer; Tang, Patrick; Patrick, David, (Physician)
Abstract
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness. Symptoms include profound fatigue and distinctive post-exertional malaise (PEM). We asked whether a submaximal exercise test would prove useful for identifying different patterns of tissue oxygen utilization in individuals with ME/CFS versus healthy subjects. Such a test has potential to aid with ME/CFS diagnosis, or to characterize patients’ illness. Methods: A case–control study of 16 patients with ME/CFS compared to 16 healthy controls completing a 3-min handgrip protocol was performed. Response was measured using near-infrared spectroscopy, resulting in measurements of oxygenated (O₂Hb) and deoxygenated hemoglobin (HHb) over wrist extensors and flexors. Changes in O₂Hb (delta (d)O₂Hb) and HHb (dHHb) absorbance between the first and last contraction were calculated, as were the force–time product of all contractions, measured as tension-time index (TTI), and ratings of perceived exertion (RPE). Results: Individuals with ME/CFS demonstrated smaller dO₂Hb and dHHb than controls. However, after adjusting for TTI and change in total hemoglobin (delta (d)tHb), differences in dO₂Hb and dHHb were reduced, with large overlapping variances. RPE was significantly higher for cases than controls, particularly at rest. Conclusions: Relative to controls, participants with ME/CFS demonstrated higher RPE, lower TTI, and reduced dO₂Hb and dHHb during repetitive handgrip exercise, although considerable variance was observed. With further study, submaximal exercise testing may prove useful for stratifying patients with a lower propensity for inducing PEM, and have the ability to establish baseline intensities for exercise prescription.
Item Metadata
Title |
Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: a case–control study
|
Creator | |
Contributor | |
Publisher |
BioMed Central
|
Date Issued |
2015-05-20
|
Description |
Background:
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness. Symptoms include profound fatigue and distinctive post-exertional malaise (PEM). We asked whether a submaximal exercise test would prove useful for identifying different patterns of tissue oxygen utilization in individuals with ME/CFS versus healthy subjects. Such a test has potential to aid with ME/CFS diagnosis, or to characterize patients’ illness.
Methods:
A case–control study of 16 patients with ME/CFS compared to 16 healthy controls completing a 3-min handgrip protocol was performed. Response was measured using near-infrared spectroscopy, resulting in measurements of oxygenated (O₂Hb) and deoxygenated hemoglobin (HHb) over wrist extensors and flexors. Changes in O₂Hb (delta (d)O₂Hb) and HHb (dHHb) absorbance between the first and last contraction were calculated, as were the force–time product of all contractions, measured as tension-time index (TTI), and ratings of perceived exertion (RPE).
Results:
Individuals with ME/CFS demonstrated smaller dO₂Hb and dHHb than controls. However, after adjusting for TTI and change in total hemoglobin (delta (d)tHb), differences in dO₂Hb and dHHb were reduced, with large overlapping variances. RPE was significantly higher for cases than controls, particularly at rest.
Conclusions:
Relative to controls, participants with ME/CFS demonstrated higher RPE, lower TTI, and reduced dO₂Hb and dHHb during repetitive handgrip exercise, although considerable variance was observed. With further study, submaximal exercise testing may prove useful for stratifying patients with a lower propensity for inducing PEM, and have the ability to establish baseline intensities for exercise prescription.
|
Subject | |
Genre | |
Type | |
Language |
eng
|
Date Available |
2015-11-10
|
Provider |
Vancouver : University of British Columbia Library
|
Rights |
Attribution 4.0 International (CC BY 4.0)
|
DOI |
10.14288/1.0215871
|
URI | |
Affiliation | |
Citation |
Journal of Translational Medicine. 2015 May 20;13(1):159
|
Publisher DOI |
10.1186/s12967-015-0527-8
|
Peer Review Status |
Reviewed
|
Scholarly Level |
Faculty
|
Copyright Holder |
Miller et al.
|
Rights URI | |
Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
Attribution 4.0 International (CC BY 4.0)