UBC Faculty Research and Publications

Subretinal gene delivery using helper-dependent adenoviral vectors Wu, Linda; Lam, Simon; Cao, Huibi; Guan, Rui; Duan, Rongqi; van der Kooy, Derek; Bremner, Rod; Molday, Robert S; Hu, Jim


This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector.

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Attribution 4.0 International (CC BY 4.0)