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Subretinal gene delivery using helper-dependent adenoviral vectors Wu, Linda; Lam, Simon; Cao, Huibi; Guan, Rui; Duan, Rongqi; van der Kooy, Derek; Bremner, Rod; Molday, Robert S; Hu, Jim

Abstract

This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector.

Item Metadata

Title
Subretinal gene delivery using helper-dependent adenoviral vectors
Creator
Wu, Linda; Lam, Simon; Cao, Huibi; Guan, Rui; Duan, Rongqi; van der Kooy, Derek; Bremner, Rod; Molday, Robert S; Hu, Jim
Publisher
BioMed Central
Date Issued
2011-04-04
Description
This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector.
Genre
Article
Type
Text
Language
eng
Date Available
2015-10-24
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0135721
URI
http://hdl.handle.net/2429/55107
Affiliation
Biochemistry and Molecular Biology, Department of; Medicine, Faculty of; Non UBC
Citation
Cell & Bioscience. 2011 Apr 04;1(1):15
Publisher DOI
10.1186/2045-3701-1-15
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Wu et al; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
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DSpace

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Attribution 4.0 International (CC BY 4.0)