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A chance to stop and breathe: participants’ experiences in the North American Opiate Medication Initiative clinical trial Oviedo-Joekes, Eugenia; Marchand, Kirsten; Lock, Kurt; Chettiar, Jill; Marsh, David C.; Brissette, Suzanne; Anis, Aslam H. (Aslam Hayat), 1959-; Schechter, Martin T.

Abstract

Background. The North American Opiate Medication Initiative (NAOMI) clinical trial compared the effectiveness of injectable diacetylmorphine (DAM) or hydromorphone (HDM) to oral methadone maintenance treatment (MMT). This study aimed to determine participants’ perceptions of treatment delivered in NAOMI. Methods A qualitative sub-study was conducted with 29 participants (12 female): 18 (62.1%) received injectable DAM or HDM and 11 (37.9%) received MMT. A phenomenological theoretical framework was used. Semi-structured interviews were audio-recorded and transcribed verbatim. A thematic analysis was used over successive phases and was driven by the semantic meanings of the data. Results Participants receiving injectable medications suggested that the supervised delivery model was stringent but provided valuable stability to their lives. Females discussed the adjustment required for the clinical setting, while males focused on the challenging clinic schedule and its impact on employment abilities. Participants receiving MMT described disappointment with being randomized to this treatment; however, positive aspects, including the quick titration time and availability of auxiliary services, were also discussed. Conclusion Treatment with injectable DAM (or HDM) is preferred by participants and considered effective in reducing the burden of opioid dependency. Engaging patients in research regarding their perceptions of treatment provides a comprehensive assessment of treatment needs and barriers. Clinical trial registration NCT00175357

Item Metadata

Title
A chance to stop and breathe: participants’ experiences in the North American Opiate Medication Initiative clinical trial
Creator
Oviedo-Joekes, Eugenia; Marchand, Kirsten; Lock, Kurt; Chettiar, Jill; Marsh, David C.; Brissette, Suzanne; Anis, Aslam H. (Aslam Hayat), 1959-; Schechter, Martin T.
Publisher
BioMed Central
Date Issued
2014-09-29
Description
Background. The North American Opiate Medication Initiative (NAOMI) clinical trial compared the effectiveness of injectable diacetylmorphine (DAM) or hydromorphone (HDM) to oral methadone maintenance treatment (MMT). This study aimed to determine participants’ perceptions of treatment delivered in NAOMI. Methods A qualitative sub-study was conducted with 29 participants (12 female): 18 (62.1%) received injectable DAM or HDM and 11 (37.9%) received MMT. A phenomenological theoretical framework was used. Semi-structured interviews were audio-recorded and transcribed verbatim. A thematic analysis was used over successive phases and was driven by the semantic meanings of the data. Results Participants receiving injectable medications suggested that the supervised delivery model was stringent but provided valuable stability to their lives. Females discussed the adjustment required for the clinical setting, while males focused on the challenging clinic schedule and its impact on employment abilities. Participants receiving MMT described disappointment with being randomized to this treatment; however, positive aspects, including the quick titration time and availability of auxiliary services, were also discussed. Conclusion Treatment with injectable DAM (or HDM) is preferred by participants and considered effective in reducing the burden of opioid dependency. Engaging patients in research regarding their perceptions of treatment provides a comprehensive assessment of treatment needs and barriers. Clinical trial registration NCT00175357
Subject
Opioid dependency; Diacetylmorphine; Injectable; Oral methadone; Opioid maintenance treatment; Qualitative methods
Geographic Location
Downtown-Eastside (Vancouver, B.C.)
Genre
Article
Type
Text
Language
eng
Date Available
2015-08-26
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0074656
URI
http://hdl.handle.net/2429/54652
Affiliation
Population and Public Health (SPPH), School of; Non UBC; Medicine, Faculty of
Citation
Addiction Science & Clinical Practice. 2014 Sep 29;9(1):21
Publisher DOI
10.1186/1940-0640-9-21
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Oviedo-Joekes et al.; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)