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The immunoregulatory mechanisms of carcinoma for its survival and development Du, Caigan; Wang, Yuzhuo, Ph.D.

Abstract

The immune system in patients detects and eliminates tumor cells, but tumors still progress persistently. The mechanisms by which tumor cells survive under the pressure of immune surveillance are not fully understood. This review is to present the evidence from clinical studies, showing a significant correlation of clinicopathological features of carcinoma with: (1) the loss of classical human leukocyte antigen class I, (2) the up-regulation of non-classical human leukocyte antigen class I, pro-apoptotic Fas ligand and receptor-binding cancer antigen expressed on SiSo cells I, and (3) the formation of immunosuppressive microenvironment by up-regulation of transforming growth factor-beta, Galectin-1, inhibitory ligand B7s, indoleamine 2,3-dioxygenase and arginase, as well as by recruitment of tumor-induced myeloid-derived suppressor cells and regulatory T cells. All of these factors may together protect carcinoma cells from the immune-cytotoxicity.

Item Metadata

Title
The immunoregulatory mechanisms of carcinoma for its survival and development
Creator
Du, Caigan; Wang, Yuzhuo, Ph.D.
Publisher
BioMed Central
Date Issued
2011-01-21
Description
The immune system in patients detects and eliminates tumor cells, but tumors still progress persistently. The mechanisms by which tumor cells survive under the pressure of immune surveillance are not fully understood. This review is to present the evidence from clinical studies, showing a significant correlation of clinicopathological features of carcinoma with: (1) the loss of classical human leukocyte antigen class I, (2) the up-regulation of non-classical human leukocyte antigen class I, pro-apoptotic Fas ligand and receptor-binding cancer antigen expressed on SiSo cells I, and (3) the formation of immunosuppressive microenvironment by up-regulation of transforming growth factor-beta, Galectin-1, inhibitory ligand B7s, indoleamine 2,3-dioxygenase and arginase, as well as by recruitment of tumor-induced myeloid-derived suppressor cells and regulatory T cells. All of these factors may together protect carcinoma cells from the immune-cytotoxicity.
Genre
Article
Type
Text
Language
eng
Date Available
2015-08-25
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0074630
URI
http://hdl.handle.net/2429/54617
Affiliation
Medicine, Faculty of; Urologic Sciences, Department of; Non UBC
Citation
Journal of Experimental & Clinical Cancer Research. 2011 Jan 21;30(1):12
Publisher DOI
10.1186/1756-9966-30-12
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Du and Wang; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
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Attribution 4.0 International (CC BY 4.0)