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Biology and physiology of Calbindin-D9k in female reproductive tissues: Involvement of steroids and endocrine disruptors Choi, Kyung-Chul; Leung, P. C. K.; Jeung, Eui-Bae

Abstract

Although Calbindin-D9k (CaBP-9k), a cytosolic calcium binding protein which has calcium binding sites, is expressed in various tissues, i.e., intestine, uterus, and placenta, potential roles of this gene and its protein are not clearly understood. Uterine CaBP-9k may be involved in controlling myometrial activity related with intracellular calcium level and is not under the control of vitamin D despite the presence of vitamin D receptors. But, it is under the control of the sex steroid hormones, estrogen (E2) and progesterone (P4), in female reproductive systems including the uterus and placenta. Thus, in this review, we summarize recent research literature in regards to the expression and regulation of CaBP-9k in mammals and introduce the research data of recent studies by us and others.

Item Metadata

Title
Biology and physiology of Calbindin-D9k in female reproductive tissues: Involvement of steroids and endocrine disruptors
Creator
Choi, Kyung-Chul; Leung, P. C. K.; Jeung, Eui-Bae
Contributor
Child and Family Research Institute
Publisher
BioMed Central
Date Issued
2005-11-16
Description
Although Calbindin-D9k (CaBP-9k), a cytosolic calcium binding protein which has calcium binding sites, is expressed in various tissues, i.e., intestine, uterus, and placenta, potential roles of this gene and its protein are not clearly understood. Uterine CaBP-9k may be involved in controlling myometrial activity related with intracellular calcium level and is not under the control of vitamin D despite the presence of vitamin D receptors. But, it is under the control of the sex steroid hormones, estrogen (E2) and progesterone (P4), in female reproductive systems including the uterus and placenta. Thus, in this review, we summarize recent research literature in regards to the expression and regulation of CaBP-9k in mammals and introduce the research data of recent studies by us and others.
Genre
Article
Type
Text
Language
eng
Date Available
2015-08-19
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0074623
URI
http://hdl.handle.net/2429/54527
Affiliation
Non UBC; Obstetrics and Gynaecology, Department of; Medicine, Faculty of
Citation
Reproductive Biology and Endocrinology. 2005 Nov 16;3(1):66
Publisher DOI
10.1186/1477-7827-3-66
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Choi et al.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)