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Triple-marker screening in British Columbia : current practice, future options : final report made to the Minister's Advisory Council on Women's Health Bassett, Kenneth, 1952-; Lee, Patricia M. (Patricia Mary), 1945-; Green, C. J. (Carolyn Joanne), 1956-; Mitchell, Lisa; Sroka, Hana; Lal, Rohinee; Hanvelt, Robin; Kazanjian, Arminée, 1947-; Fletcher, Garry
Abstract
The purpose of this review is to examine maternal serum triple-marker screening (TMS) for fetuses with Down syndrome, other chromosomal abnormalities, and spina bifida, in the British Columbia context. Evaluation is both qualitative, addressing the personal and social significance of TMS, and quantitative, assessing effectiveness and cost. The review is organized around the evaluation of four possible options for funding TMS. The first three options are in essence variations on current TMS practice in the province. A fourth option adds co-ordination of TMS, that is, provision, standardization, evaluation, and education throughout the province. In the interest of clarity, the options are discussed as much as possible in relation to Down syndrome, the most common condition traced through TMS. The review has been conducted with particular attention to the interests of groups who may in some respects be seen as vulnerable, women during pregnancy and members of the Down syndrome community; and also to the concerns of TMS providers. The issues examined are those relevant to large-scale population screening of women considered at low pre-test risk of carrying an affected fetus. Not addressed are issues of particular relevance to women identified as being at high pre-test risk owing to individual or family history of affected births.
Item Metadata
| Title |
Triple-marker screening in British Columbia : current practice, future options : final report made to the Minister's Advisory Council on Women's Health
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| Alternate Title |
BCOHTA 00:14T
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| Creator | |
| Contributor | |
| Publisher |
British Columbia Office of Health Technology Assessment (BCOHTA)
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| Date Issued |
2000-07
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| Description |
The purpose of this review is to examine maternal serum triple-marker screening (TMS) for fetuses with Down syndrome, other chromosomal abnormalities, and spina bifida, in the British Columbia context. Evaluation is both qualitative, addressing the personal and social significance of TMS, and quantitative, assessing effectiveness and cost.
The review is organized around the evaluation of four possible options for funding TMS. The first three options are in essence variations on current TMS practice in the province. A fourth option adds co-ordination of TMS, that is, provision, standardization, evaluation, and education throughout the province. In the interest of clarity, the options are discussed as much as possible in relation to Down syndrome, the most common condition traced through TMS.
The review has been conducted with particular attention to the interests of groups who may in some respects be seen as vulnerable, women during pregnancy and members of the Down syndrome community; and also to the concerns of TMS providers. The issues examined are those relevant to large-scale population screening of women considered at low pre-test risk of carrying an affected fetus. Not addressed are issues of particular relevance to women identified as being at high pre-test risk owing to individual or family history of affected births.
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| Subject |
Medical technology; Health technology; Prenatal diagnosis; Medical screening -- British Columbia; Down syndrome -- Diagnosis; Women's health services -- Government policy -- British Columbia; Fetal Diseases; Genetic Screening -- Pregnancy; Hematologic Tests -- Pregnancy; alpha-Fetoproteins -- diagnostic use; Chromosome Aberrations -- diagnosis; Spina Dysrathism -- diagnosis; Public Policy -- British Columbia; Women's Health Services -- British Columbia
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| Geographic Location | |
| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2014-10-08
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivs 2.5 Canada
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| DOI |
10.14288/1.0045274
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| URI | |
| Affiliation | |
| Peer Review Status |
Reviewed
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| Scholarly Level |
Faculty; Researcher; Graduate
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivs 2.5 Canada