Assessment of knee cartilage mechanics using the magnetization transfer ratio
department or school: Applied Science, Faculty of
department or school: Biomedical Engineering, School of
data provider: DSpace
degree campus: UBCV
creator: Sullivan, Emily
issued: 2023-03-24T22:18:35Z
issued: 2023
related degree: Master of Applied Science - MASc
degree grantor: University of British Columbia
description: Introduction: Osteoarthritis (OA) is a debilitating disease caused by abnormal joint mechanics. There is a need for a non-invasive method to identify the specific mechanical changes that lead to OA. Magnetic resonance imaging (MRI) techniques such as T2 and T1ρ have shown sensitivity to mechanical changes in cartilage. However, the response is depth-dependent, and clinical MRI scanners with lower image resolutions cannot detect such specific changes. The magnetization transfer ratio (MTR) is a newer MRI metric that has shown promise as a measure of cartilage strain and stiffness. This research aimed to validate MTR as a robust method to measure loaded deformation and stiffness of knee cartilage. Methods: Three phases of work are described: first, an electropneumatic compressive loading device was developed and validated to apply step compressive forces to cartilage specimens in a high-resolution small-bore 9.4 Tesla MRI scanner. Second, bovine tibiofemoral osteochondral samples were compressed using this device while acquiring MTR and T2 data, and the correlations between cartilage strain and MTR/T2 were analyzed to determine any significant relationships. Finally, instantaneous stiffness maps were acquired across the same specimens via indentation testing. The relationship between local instantaneous modulus and local MTR/T2 were then assessed. Results: The loading device was successfully developed and validated to apply step compressive loads to cartilage samples in a small-bore MRI. Uniform MTR differences were observed through the cartilage thickness with increasing strain, whereas the T2 reaction to strain was regionally dependent. The relationship between MTR and strain was also found to be less specimen dependent (rrm = -0.25 to -0.36) than the relationship between T2 and strain (rrm = -0.28 iv to 0.21). When assessing correlations between local MTR/T2 and local instantaneous modulus, neither MRI metrics were found to be strong predictors of cartilage stiffne…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/84060
note: ASSESSMENT OF KNEE CARTILAGE MECHANICS USING THE MAGNETIZATION TRANSFER RATIO by EMILY SULLIVAN BASc, The University of British Columbia, 2020 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF APPLIED SCIENCE in THE FACULTY OF GRADUATE AND POSTDOCTORAL STUDIES (Biomedical Engineering) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) March 2023 © Emily Sullivan, 2023 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, the thesis entitled: Assessment of knee cartilage mechanics using the magnetization transfer ratio submitted by Emily Sullivan in partial fulfilment of the requirements for the degree of Master of Applied Science in Biomedical Engineering Examining Committee: Dr. David Wilson, Professor, Department of Orthopaedics, UBC Supervisor Dr. Thomas Oxland, Professor, Departments of Orthopaedics and Mechanical Engineering, UBC Supervisory Committee Member Dr. Jessica Kupper, Post Doctoral Fellow, Department of Orthopaedics, UBC Supervisory Committee Member Dr. Roger Tam, Associate Professor, Departments of Radiology and Biomedical Engineering, UBC Supervisory Committee Member iii Abstract Introduction: Osteoarthritis (OA) is a debilitating disease caused by abnormal joint mechanics. There is a need for a non-invasive method to identify the specific mechanical changes that lead to OA. Magnetic resonance imaging (MRI) techniques such as T2 and T1ρ have shown sensitivity to mechanical changes in cartilage. However, the response is depth-dependent, and clinical MRI scanners with lower image resolutions cannot detect such specific changes. The magnetization transfer ratio (MTR) is a newer MRI metric that has shown promise as a measure of cartilage strain and stiffness. This research aimed to validate MTR as a robust method to measure loaded deformation and stiffness of knee cartilage. Methods: Three phases of work are described: first, an elec…
has type: Thesis/Dissertation
date issued: 2023-05
is shown at: 10.14288/1.0428583
language: eng
degree discipline: Biomedical Engineering
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
contributor: Wilson, David R.
type: Text
identifier URI: http://hdl.handle.net/2429/84060