Application of myelin water imaging to detect diffuse white matter damage in multiple sclerosis
department or school: Medicine, Faculty of
department or school: Medicine, Department of
data provider: DSpace
degree campus: UBCV
creator: Lee, Eun Young (Lisa)
issued: 2019-01-10T17:06:23Z
issued: 2019
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: While conventional magnetic resonance imaging (MRI) is qualitatively useful for the diagnosis and clinical management of multiple sclerosis (MS), it has limitations in terms of detecting specific myelin loss and diffuse damage in the normal-appearing white matter. A non-conventional MRI technique, called myelin water imaging (MWI) can be achieved using multicomponent T₂ relaxation to provide a quantitative in vivo measurement of myelin, termed myelin water fraction (MWF). MWF has been proposed as a candidate MR marker of myelin content in the central nervous system. In this study, I present the application of MWI to gain a deeper insight into the diffuse white matter damage in MS. First, we found lower myelin content and higher myelin heterogeneity in brain and cervical spinal cord, as well as correlations between myelin heterogeneity and clinical disability in cervical spinal cord in progressive MS compared to healthy controls. We also found myelin abnormalities in the regional and global white matter in progressive solitary sclerosis, which has recently been proposed as a potential variant of MS. Finally, we demonstrated good global white matter MWF reproducibility (coefficient of variation = 2.77 %; Pearson’s r = 0.91, p < 0.001; mean bias = 0.002) between two sites using different scanner vendors. Together, our findings support that MWI is a useful quantitative imaging technique that may be used to improve our understanding of the pathological processes in MS. Furthermore, inter-vendor reproducibility takes MWI a step closer to routine use for multicenter studies and clinical applications.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/68228
note: APPLICATION OF MYELIN WATER IMAGING TO DETECT DIFFUSE WHITE MATTER DAMAGE IN MULTIPLE SCLEROSIS by Eun Young (Lisa) Lee B.Sc., The University of British Columbia, 2015 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in The Faculty of Graduate and Postdoctoral Studies (Experimental Medicine) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) January 2019 © Eun Young (Lisa) Lee, 2019 ii The following individuals certify that they have read, and recommend to the Faculty of Graduate and Postdoctoral Studies for acceptance, a thesis/dissertation entitled: Application of myelin water imaging to detect diffuse white matter damage in multiple sclerosis submitted by Eun Young (Lisa) Lee in partial fulfillment of the requirements for the degree of Master of Science in Experimental Medicine Examining Committee: Dr. Shannon Kolind, Medicine (Neurology) Supervisor Dr. Anthony Traboulsee, Medicine (Neurology) Supervisor Dr. Robert Carruthers, Medicine (Neurology) Supervisory Committee Member Dr. Carles Vilarino-Guell, Medicine (Medical Genetics) Supervisory Committee Member Dr. Joanne Weinberg, Cellular and Physiological Sciences Additional Examiner iii Abstract While conventional magnetic resonance imaging (MRI) is qualitatively useful for the diagnosis and clinical management of multiple sclerosis (MS), it has limitations in terms of detecting specific myelin loss and diffuse damage in the normal-appearing white matter. A non-conventional MRI technique, called myelin water imaging (MWI) can be achieved using multicomponent T2 relaxation to provide a quantitative in vivo measurement of myelin, termed myelin water fraction (MWF). MWF has been proposed as a candidate MR marker of myelin content in the central nervous system. In this study, I present the application of MWI to gain a deeper insight into the diffuse white matter damage in MS. First, we found lower myelin content and higher myelin heterogeneity in brain and cervical spinal…
has type: Thesis/Dissertation
date issued: 2019-02
is shown at: 10.14288/1.0376036
language: eng
degree discipline: Experimental Medicine
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: Attribution-NonCommercial-NoDerivatives 4.0 International
rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/68228