A study of some pharmacological properties of certain alpha-glyceryl ethers.
department or school: Pharmaceutical Sciences, Faculty of
data provider: DSpace
degree campus: UBCV
creator: Klier, Gail Dianne Bellward
issued: 2011-12-14T02:54:36Z
issued: 1963
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: The alpha-glyceryl ethers (AGE) are widely distributed in nature, occurring in many marine organisms, land animals, plants, and humans. A series of preliminary experiments was begun to determine whether these compounds possessed possible pharmacological actions against inflammation. Anti-inflammatory tests utilized both the granuloma pouch and cotton pellet granulation methods. Possible glucocorticoid activity was checked by measuring liver glycogen deposition. The effects of AGE on growth and weight of the animals was also noted. Neither selachyl dihemisuccinate sodium (selachyl DHSS) nor selachyl alcohol decreased the exudate formation in the granuloma pouch experiments, although excellent results were obtained with hydrocortisone. The high dose of the AGE was the equivalent of ten milligrams; low doses were three hundred and six hundred micrograms. Routes of administration used were oral, intraperitoneal, and subcutaneous. In the cotton pellet granuloma test, some indication of anti-inflammatory activity was obtained, in accordance with previous results in this and other laboratories. Selachyl DHSS decreased granulation tissue formation by only 11.7% in growing rats, which is not significant; however, in mature rats, there was a decrease of 29.5%. The dosage used in this series was 30 milligrams per kilogram daily by the subcutaneous route, A definite and comparatively large increase in liver glycogen deposition was observed in rats allowed to eat freely, when given selachyl DHSS subcutaneously. These glycogen values were decreased radically by a paired feeding study in which the treated rats were allowed to eat only the same amount of food as their paired control animal. Thus food intake appears to be one of the factors responsible for the increased glycogen storage. The AGE appear to affect growth only by the Intraperitoneal route of administration. In this case, the growth of rats was retarded by 29.6%. It was also noted that these animals ate somewhat less fo…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/39678
note: A STUDY OP SOME PHARMACOLOGICAL PROPERTIES OP CERTAIN ALPHA-GLYCERYL ETHERS by GAIL DIANNE BELLWARD KLIER A thes is submitted i n p a r t i a l f u l l f i l m e n t of the requirements f o r the degree of MASTER OP SCIENCE IN PHARMACY i n the D i v i s i o n of Pharmacology of the Facu l ty of Pharmacy We accept t h i s thes is as conforming to the requi red standard THE UNIVERSITY OF BRITISH COLUMBIA October, 1963 In presenting t h i s t h e s i s i n p a r t i a l f u l f i l m e n t of the requirements for an advanced degree at the U n i v e r s i t y of B r i t i s h Columbia, I agree that the L i b r a r y s h a l l make i t f r e e l y a v a i l a b l e for reference and .study. I further agree that per-mission for extensive copying of t h i s t h e s i s f o r s c h o l a r l y purposes may be granted by the Head of my Department or by h i s representatives,, I t i s understood that copying, or p u b l i -c a t i o n of t h i s t h e s i s f o r f i n a n c i a l gain s h a l l not be allowed without my w r i t t e n permission. The U n i v e r s i t y of B r i t i s h Columbia,. Vancouver 8 , Canada. Department of Date i A STUDY OP SOME PHARMACOLOGICAL PROPERTIES OP CERTAIN ALPHA-GLYCERYL ETHERS by GAIL DIANNE BELLWARD KLIER ABSTRACT The alpha-glyceryl ether3 (AGE) are widely d i s t r i b u t e d i n nature, occurring i n many marine organisms, land animals, plants, and humans. A series of preliminary experiments was begun to determine whether these compounds possessed possible pharm-acol o g i c a l actions against inflammation. Anti-inflammatory tests u t i l i z e d both the granuloma pouch and cotton p e l l e t granulation methods. Possible g l u c o c o r t i c o i d a c t i v i t y was checked by measuring l i v e r glycogen deposition. The effects of AGE on growth and weight of the animals was also noted. Neither selachyl dihemisuccinate sodium (selachyl DHSS) nor selachyl alcohol decreased the exudate formation i n the granuloma pouch experiments,…
has type: Thesis/Dissertation
is shown at: 10.14288/1.0105968
language: eng
degree discipline: Pharmacy
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/39678