A study of rhabdomyosarcomas induced by nickel sulphide in rats.
department or school: Medicine, Faculty of
department or school: Cellular and Physiological Sciences, Department of
data provider: DSpace
degree campus: UBCV
creator: Capstick, Valerie
issued: 2011-10-31T17:37:32Z
issued: 1963
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: The study of rhabdomyosarcomas induced by nickel sulphide was undertaken in order to investigate their growth and responsiveness characteristics and to evaluate their possible usefulness as experimental tumour systems. A study was also made on the carcinogenic specificity of nickel sulphide. Intramuscular injections of 0.5 to 20 mg. of Ni₃S₂ resulted in tumours after two to six months, which grew fairly rapidly, once palpable. On transplantation they proved to be highly malignant, causing 100 per cent takes within approximately two weeks and death of the host within three to eight weeks. Detailed histological study was performed on many sections of tumour and muscle in order to establish identity of the rhabdomyosarcomas and to observe such cytological phenomena as muscle degeneration, tissue disruption and development of anaplasia. The carcinogenic activity of Ni₃S₂ was emphasized by the rapidity of tumour induction observed after very low doses, while the difference in latent periods suggested some correlation between dose and response. Injections of Ni₃S₂ into body organs illustrated the extreme toxicity of the substance in individual tissues. Although results were somewhat inconclusive within the time limit of the experiment, the general tenor of the data suggested that Ni₃S₂ had a toxic rather than tumourigenic action on most tissues. The appearance of rhabdomyosarcomas when the compound was in contact with abdominal or leg musculature gave evidence that nickel sulphide might have some specificity for striated muscle. Preliminary experiments with NiS indicated that its carcinogenicity, if any, was considerably less than that of Ni₃S₂, with different solubility in muscle being a possible explanation. Several of the induced tumours were used for metabolic and experimental therapy studies with various compounds. Numerous experiments indicated that the tumour was essentially unreliable for such studies since growth rates and response were not reproducible in differ…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/38451
note: A STUDY OF RHABDOMYOSARCOMAS INDUCED BY NICKEL SULPHIDE IN RATS by VALERIE CAPSTICK B . S c , The U n i v e r s i t y o f B r i t i s h Columbia, 1961 A THESIS SUBMITTED IN PARTIAL'FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE i n the Department, of P h y s i o l o g y We accept t h i s t h e s i s as conforming to the r e q u i r e d standard THE UNIVERSITY OF BRITISH COLUMBIA A p r i l , 1963 In presenting this thesis'in p a r t i a l fulfilment of the requirements for an advanced degree at the University of B r i t i s h Columbia, I agree that the Library sh a l l make i t freely available for reference and study. I further agree that per-mission for extensive copying of this thesis for scholarly purposes may be granted by the Head of my Department or by his'.representatives..- It i s understood'that copying, or publi-. cation of this thesis for f i n a n c i a l :gain shall not be allowed . without my written permission. Department 0 f Physiology The University of B r i t i s h Columbia, Vancouver 8 , Canada. Date A p r i l , 1963 ABSTRACT The study o f rhabdomyosarcomas induced by n i c k e l s u l p h i d e was undertaken i n order to i n v e s t i g a t e t h e i r growth and r e s p o n s i v e n e s s c h a r a c t e r i s t i c s and to e v a l u a t e t h e i r p o s s i b l e u s e f u l n e s s as experimental tumour systems. A study was a l s o made on the c a r c i n o g e n i c s p e c i f i c i t y o f n i c k e l s u l p h i d e . Intramuscular i n j e c t i o n s of 0.5 to 20 mg. of Ni^S2 r e s u l t e d i n tumours a f t e r two to s i x months, which grew f a i r l y r a p i d l y , once p a l p a b l e . On t r a n s p l a n t a t i o n they proved to be h i g h l y malignant, causing 100 per cent takes w i t h i n a p p r o x i -mately two weeks and death of the h o s t w i t h i n three to e i g h t weeks. D e t a i l e d h i s t o l o g i c a l study was performed on many s e c t i o n s of tumour and muscle i n order to…
has type: Thesis/Dissertation
is shown at: 10.14288/1.0105501
language: eng
degree discipline: Physiology
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/38451