Six Tc-99m labelled dibasic acids : an investigation of their potential use as scintiscanning agents
department or school: Pharmaceutical Sciences, Faculty of
data provider: DSpace
degree campus: UBCV
creator: McOrmond, Philip Murray
issued: 2010-01-28T21:46:53Z
issued: 1975
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Six low molecular weight dibasic acids labelled with technetium -99m were investigated for their potential use as scanning agents. Preliminary radioscintiscans of rabbits showed the main areas of localization for all the acids. From this study, the most promising of the compounds, malonic acid, was chosen for further investigation. Toxicity studies were performed on mice using a complex of stannous chloride and malonic acid given intravenously. The LD₅₀ for the complex was determined to be 800 (734-872) mg/kg. The excretion rate of the labelled complex was examined in mice and the activity was found to be eliminated in two components. The fast component had a half-life of 46.8 minutes, and consisted of 70.3 percent of the administered dose; the slow component, accounting for the remainder of the administered dose, had a half-life of 196.4 minutes. The excreted urine was found to contain the entire injected dose. The tissue distribution of technetium -99m - malonate in mice was analyzed with the highest concentration of activity occurring in the kidneys and blood. The liver, spleen, large and small bowels, brain, stomach, lungs, bone, and muscle were also investigated for their content of the labelled complex. Scintiscans were done on rabbits using technetium -99m - malonate to determine the dynamic flow pattern of the complex and to evaluate the scans at various time intervals after injection. A renogram was obtained using the Dyna Camera® to record the pattern of activity through the kidneys. This curve demonstrated that a fast component of excretion with a half-life of 5.5 minutes exists in the rabbit kidney. Absorbed dose calculations were computed for the whole body, kidney, liver, skeleton, and bladder. The bladder component was computed twice, once assuming complete urine retention and again assuming catheterization. The radiation doses were calculated as 26 mrads/ 10 mCi. for the whole body, 159 mrads/10 mCi. for the kidneys, 103 mrads/ 10 mCi. for the liver,…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/19294
note: S I X TC-9'9M L A B E L L E D D I B A S I C A C I D S : AN I N V E S T I G A T I O N OF T H E I R P O T E N T I A L USE AS S C I N T I S C A N N I N G AGENTS by PHILIP MURRAY McORMOND B. S c , U n i v e r s i t y of V i c t o r i a , 1969 B.Sc.(Pharm.), U n i v e r s i t y of B r i t i s h Columbia, 1973 A THESIS SUBMITTED IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE i n the Department of Pharmaceutical Sciences We accept t h i s t h e s i s as conforming to the requ i r e d standard THE UNIVERSITY OF BRITISH COLUMBIA September, 1975 In present ing th is thes is in p a r t i a l fu l f i lment of the requirements for an advanced degree at the Un ivers i ty of B r i t i s h Columbia, I agree that I fur ther agree that permission for extensive copying of th is thes is for s c h o l a r l y purposes may be granted by the Head of my Department or by h is representa t ives . It i s understood that copying or p u b l i c a t i o n of th is thes is fo r f i n a n c i a l gain sha l l not be allowed without my wri t ten permission. the L ibrary sha l l make it f r ee ly ava i l ab le for reference and study. Department of Pk t L f ^ t e ^ i ' c «J The Univers i ty of B r i t i s h Columbia 2075 Wesbrook Place Vancouver, Canada V6T 1W5 Date ABSTRACT Six low molecular weight dibasic acids labelled with tech-netium -99m were investigated for their potential use as scanning agents. Preliminary radioscintiscans of rabbits showed the main areas of localization for a l l the acids. From this study, the most promising of the compounds, malonic acid, was chosen for further investigation. Toxicity studies were performed on mice using a complex of stannous chloride and malonic acid given intravenously. The L°^Q for the complex was determined to be 800 (734-872) mg/kg. The excretion rate of the labelled complex was examined in mice and the activity was found to be eliminated in two components. The fast component had a h a l f - l i f e of 46.8 minutes, …
has type: Thesis/Dissertation
is shown at: 10.14288/1.0100027
language: eng
degree discipline: Pharmaceutical Sciences
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/19294