Long-lasting potentiation and depression of synaptic responses in the hippocampus
department or school: Medicine, Faculty of
department or school: Anesthesiology, Pharmacology and Therapeutics, Department of
data provider: DSpace
degree campus: UBCV
creator: Goh, Joanne Wan Yoong
issued: 2010-05-12T16:10:31Z
issued: 1984
related degree: Master of Science - MSc
degree grantor: University of British Columbia
description: Tetanic stimulations when applied to the Schaffer collaterals or the commissural input to CA₁ neurones in the mammalian hippocampus results in a long-lasting potentiation (LLP) of synaptic transmission across the tetanized synapse (Andersen et al., 1977; Schwartzkroin and Wester 1975). The induction of LLP is dependent on the extracellular Ca⁺⁺ concentration (Dunwiddie and Lynch, 1979; Wigstrom et al., 1979) but whether it is generated pre- and/or postsynaptically is at present unresolved. Transient homo- and heterosynaptic depressions of the CA₁ population spike have been reported following low frequency (I-20 Hz) tetani to hippocampal inputs (Lynch et al., 1977; Alger et al., 1978) which precede the observation of homosynaptic LLP (Dunwiddie and Lynch, 1978). The present studies were conducted to 1) test the hypothesis of Baudry and Lynch (1980a) who think that LLP can be explained postsynaptically by a Ca⁺⁺ dependent increase in the number of transmitter receptors; 2) examine the effects of verapamil (a Ca⁺⁺ antagonist that blocks CA₁ neuronal Ca⁺⁺ currents [Griffith and Brown, 1982] without interfering with transmitter release [Nachshen and Blaustein, 1979]) on the induction of LLP and homo- and heterosynaptic depressions; 3) investigate the Ca⁺⁺ dependence of a decrease in presynaptic terminal excitability that is associated with LLP (Sastry, 1982) and 4) examine the suggestion of Collingridge et al., (1983b) that N-methyl-DL-aspartate preferring amino acid receptors are involved in the induction of LLP. The studies conducted led to the conclusions that 1) LLP is probably generated presynaptically and depression of synaptic responses is localized to the postsynaptic neurone; 2) verapamil appears to antagonize Ca++-dependent depression postsynaptically but it does not block the induction of Ca⁺⁺ dependent LLP; 3) the decrease in excitability of Schaffer collateral terminal regions which correlates with LLP is Ca⁺⁺ dependent but insensitive to verapamil and 4) N-…
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/24616
note: LONG-LASTING POTENTIATION AND DEPRESSION OF SYNAPTIC RESPONSES IN THE HIPPOCAMPUS By JOANNE WAN YOONG GOH B.Sc. (Pharm.), The University of Brit ish Columbia, 1981 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE STUDIES (Department of Pharmacology & Therapeutics) We accept this thesis as conforming to the required standard THE UNIVERSITY OF BRITISH COLUMBIA April 1984 © J o a n n e Wan Yoong Goh, 1984 In p r e s e n t i n g t h i s t h e s i s i n p a r t i a l f u l f i l m e n t o f the requirements f o r an advanced degree a t the U n i v e r s i t y o f B r i t i s h Columbia, I agree t h a t the L i b r a r y s h a l l make i t f r e e l y a v a i l a b l e f o r r e f e r e n c e and study. I f u r t h e r agree t h a t p e r m i s s i o n f o r e x t e n s i v e copying o f t h i s t h e s i s f o r s c h o l a r l y purposes may be granted by the head o f my department o r by h i s o r her r e p r e s e n t a t i v e s . I t i s understood t h a t copying o r p u b l i c a t i o n o f t h i s t h e s i s f o r f i n a n c i a l g a i n s h a l l not be allowed without my w r i t t e n p e r m i s s i o n . .Department o f Pharmacology & Therapeutics The U n i v e r s i t y o f B r i t i s h Columbia 1956 Main Mall Vancouver, Canada V6T 1Y3 Date April 2, 1984 - i i -ABSTRACT Tetanic stimulations when applied to the Schaffer col laterals or the commissural input to CA^ neurones in the mammalian hippocampus results in a long-lasting potentiation (LLP) of synaptic transmission across the tetanized synapse (Andersen et a l . , 1977; Schwartzkroin and Wester 1975). The induction of LLP is dependent on the extracellular C a + + concentration (Dunwiddie and Lynch, 1979; Wigstrom et a l . , 1979) but whether i t is generated pre- and/or postsynaptically is at present unresolved. Transient homo- and heterosynaptic depressions of the CA-^ population spike have been reported following low frequ…
has type: Thesis/Dissertation
date issued: 1984-05
is shown at: 10.14288/1.0096067
language: eng
degree discipline: Pharmacology and Therapeutics
provider: Vancouver : University of British Columbia Library
publisher: University of British Columbia
rights: For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use.
scholar level: Graduate
type: Text
identifier URI: http://hdl.handle.net/2429/24616