Identifying Longitudinal CD4:CD8 Ratio Trajectories Indicative of Chronic Renal Disease Risk among People Living with HIV : An Application of Growth Mixture Models
department or school: Education, Faculty of
department or school: Medicine, Faculty of
department or school: Educational and Counselling Psychology, and Special Education (ECPS), Department of
department or school: Medicine, Department of
department or school: Family Practice, Department of
data provider: DSpace
identifier citation: Viruses 15 (2): 385 (2023)
contributor: Centre for Health Evaluation & Outcome Sciences
contributor: Providence Health Care (Vancouver, B.C.)
creator: Fonseca-Cuevas, Alejandra
creator: Newsome, Patrick
creator: Wang, Lu
creator: Chen, Michelle Y.
creator: Richardson, Chris G.
creator: Hull, Mark
creator: McLinden, Taylor
creator: Guillemi, Silvia
creator: Barrios, Rolando
creator: Montaner, Julio S. G.
creator: Lima, Viviane D.
issued: 2025-06-23T19:33:21Z
issued: 2023-01-29
description: The incidence of chronic kidney disease (CKD) is increasing among people living with HIV (PLWH). Routine monitoring of indicators such as CD4:CD8 ratio might improve the early detection of CKD. Our objective was to identify clinically relevant CD4:CD8 ratio trajectories indicative of CKD risk. Participants were ≥ 18 years old, initiated antiretroviral therapy between 2000 and 2016, and were followed for ≥6 months until 31 March 2017 or last contact date. Outcome was incidence of CKD. Growth mixture models (GMMs) and decay models were used to compare CD4:CD8 ratio trajectories. Following GMM, 4547 (93.5%) participants were classified in Class 1 with 5.4% developing CKD, and 316 (6.5%) participants were classified in Class 2 with 20.9% developing CKD. The final model suggested that participants in Class 2 had 8.72 times the incidence rate of developing CKD than those in Class 1. Exponential decay models indicated a significant CD4:CD8 ratio decline among Class 2 participants who developed CKD. Among those who developed CKD in Class 2, starting at 5.5 years of follow-up, the slope of their ratio trajectory curve changed significantly, and the rate of decline increased dramatically. Routine monitored CD4:CD8 ratios can be an effective strategy to identify early CKD risk among PLWH.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/91405
note: Citation: Fonseca-Cuevas, A.;Newsome, P.; Wang, L.; Chen, M.Y.;Richardson, C.G.; Hull, M.;McLinden, T.; Guillemi, S.; Barrios,R.; Montaner, J.S.G.; et al. IdentifyingLongitudinal CD4:CD8 RatioTrajectories Indicative of ChronicRenal Disease Risk among PeopleLiving with HIV: An Application ofGrowth Mixture Models. Viruses2023, 15, 385. https://doi.org/10.3390/v15020385Academic Editors: Angela Kaida,Hélène C. F. Côté, Melanie Murrayand Elizabeth KingReceived: 9 December 2022Revised: 21 January 2023Accepted: 26 January 2023Published: 29 January 2023Copyright: © 2023 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).virusesArticleIdentifying Longitudinal CD4:CD8 Ratio Trajectories Indicativeof Chronic Renal Disease Risk among People Living with HIV:An Application of Growth Mixture ModelsAlejandra Fonseca-Cuevas 1, Patrick Newsome 2, Lu Wang 1, Michelle Y. Chen 3 , Chris G. Richardson 4,Mark Hull 1,2, Taylor McLinden 1 , Silvia Guillemi 5, Rolando Barrios 1, Julio S. G. Montaner 1,2and Viviane D. Lima 1,2,*1 British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada2 Department of Medicine, Faculty of Medicine, University of British Columbia,Vancouver, BC V5Z 1M9, Canada3 Department of Educational & Counselling Psychology & Special Education, University of British Columbia,Vancouver, BC V6T 1Z4, Canada4 Centre for Health Evaluation and Outcome Sciences, Providence Health Care,Vancouver, BC V6Z 1Y6, Canada5 Department of Family Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada* Correspondence: vlima@bccfe.ca; Tel.: +1-604-806-8796Abstract: The incidence of chronic kidney disease (CKD) is increasing among people living with HIV(PLWH). Routine monitoring of indicators such as CD4:CD8 ratio might improve the early detectionof CKD. Our objective was to identi…
has type: Article
is shown at: 10.14288/1.0449170
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/v15020385
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
scholar level: Researcher
subject: CD4:CD8 ratio
subject: HIV
subject: chronic kidney disease
subject: growth mixture modeling
subject: decay model
subject: risk factors
type: Text
identifier URI: http://hdl.handle.net/2429/91405