Nociplastic Pain in Endometriosis: A Scoping Review
department or school: Medicine, Faculty of
department or school: Other UBC
department or school: Obstetrics and Gynaecology, Department of
data provider: DSpace
identifier citation: Journal of Clinical Medicine 13 (24): 7521 (2024)
contributor: Women's Health Research Institute (British Columbia)
creator: Gentles, Avonae
creator: Goodwin, Emma
creator: Bedaiwy, Yomna
creator: Marshall, Nisha
creator: Yong, Paul J.
issued: 2025-01-06T17:12:20Z
issued: 2024-12-10
description: Endometriosis is an inflammatory chronic condition associated with nociceptive, neuropathic, and nociplastic pain. Central sensitization (CS) is the primary nociplastic pain mechanism. However, there are currently no standardized methods for detecting CS or nociplastic pain. This review aims to identify available tools for characterizing CS/nociplastic pain in endometriosis-related chronic pelvic pain. Following the PRISMA-P protocol, MEDLINE, Embase, Scopus, and PsychINFO databases were searched on 23 April 2024, for the terms “endometriosis”, “central sensitization”, “nociplastic pain”, “widespread pain”, and “assessment tools”. Publications were selected if they mentioned tool(s) for detecting nociplastic pain or CS in endometriosis patients. Information was extracted on study demographics, assessment types, and the tools used for detection. Of the 379 citations retrieved, 30 papers met the inclusion criteria. When working to identify CS and nociplastic pain, fourteen studies exclusively used patient-reported questionnaires, six used quantitative sensory testing (QST), two used clinical assessments, and eight used multiple approaches combining patient-reported questionnaires and clinical assessment. This review illustrates the diversity of tools currently used to identify CS and nociplastic pain in endometriosis patients. Further research is needed to evaluate their validity and to standardize methods in order to improve the accuracy of nociplastic pain identification and guide treatment.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/90048
note: Citation: Gentles, A.; Goodwin, E.;Bedaiwy, Y.; Marshall, N.; Yong, P.J.Nociplastic Pain in Endometriosis: AScoping Review. J. Clin. Med. 2024, 13,7521. https://doi.org/10.3390/jcm13247521Academic Editor: CorneliaBachmannReceived: 22 October 2024Revised: 30 November 2024Accepted: 5 December 2024Published: 10 December 2024Copyright: © 2024 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).ReviewNociplastic Pain in Endometriosis: A Scoping ReviewAvonae Gentles 1,2 , Emma Goodwin 2, Yomna Bedaiwy 2, Nisha Marshall 1 and Paul J. Yong 1,2,3,*1 Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC V6H 3N1, Canada;avonae.gentles@cw.bc.ca (A.G.); nisha.marshall@cw.bc.ca (N.M.)2 BC Women’s Center for Pelvic Pain and Endometriosis, Vancouver, BC V6H 3N1, Canada;emma.goodwin@cw.bc.ca (E.G.); yomna04@student.ubc.ca (Y.B.)3 Women’s Health Research Institute, Vancouver, BC V6H 3N1, Canada* Correspondence: paul.yong@vch.ca; Tel.: +1-604-875-2534; Fax: +1-604-875-2569Abstract: Endometriosis is an inflammatory chronic condition associated with nociceptive, neuro-pathic, and nociplastic pain. Central sensitization (CS) is the primary nociplastic pain mechanism.However, there are currently no standardized methods for detecting CS or nociplastic pain. Thisreview aims to identify available tools for characterizing CS/nociplastic pain in endometriosis-related chronic pelvic pain. Following the PRISMA-P protocol, MEDLINE, Embase, Scopus, andPsychINFO databases were searched on 23 April 2024, for the terms “endometriosis”, “central sensiti-zation”, “nociplastic pain”, “widespread pain”, and “assessment tools”. Publications were selected ifthey mentioned tool(s) for detecting nociplastic pain or CS in endometriosis patients. Informationwas extracted on study demographics, assessment t…
has type: Article
is shown at: 10.14288/1.0447680
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/jcm13247521
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
scholar level: Researcher
subject: endometriosis
subject: nociplastic pain
subject: central sensitization
subject: peripheral sensitization
subject: pain phenotyping
type: Text
identifier URI: http://hdl.handle.net/2429/90048