Antioxidant Phytochemicals as Potential Therapy for Diabetic Complications
department or school: Medicine, Faculty of
department or school: Non UBC
department or school: Ophthalmology and Visual Sciences, Department of
data provider: DSpace
identifier citation: Antioxidants 12 (1): 123 (2023)
creator: Akpoveso, Oke-Oghene Philomena
creator: Ubah, Emeka Emmanuel
creator: Obasanmi, Gideon
issued: 2024-12-18T18:07:31Z
issued: 2023-01-04
description: The global prevalence of diabetes continues to increase partly due to rapid urbanization and an increase in the aging population. Consequently, this is associated with a parallel increase in the prevalence of diabetic vascular complications which significantly worsen the burden of diabetes. For these diabetic vascular complications, there is still an unmet need for safe and effective alternative/adjuvant therapeutic interventions. There is also an increasing urge for therapeutic options to come from natural products such as plants. Hyperglycemia-induced oxidative stress is central to the development of diabetes and diabetic complications. Furthermore, oxidative stress-induced inflammation and insulin resistance are central to endothelial damage and the progression of diabetic complications. Human and animal studies have shown that polyphenols could reduce oxidative stress, hyperglycemia, and prevent diabetic complications including diabetic retinopathy, diabetic nephropathy, and diabetic peripheral neuropathy. Part of the therapeutic effects of polyphenols is attributed to their modulatory effect on endogenous antioxidant systems. This review attempts to summarize the established effects of polyphenols on endogenous antioxidant systems from the literature. Moreover, potential therapeutic strategies for harnessing the potential benefits of polyphenols for diabetic vascular complications are also discussed.
aggregated CHO: https://circle.library.ubc.ca/rest/handle/2429/89914
note: Citation: Akpoveso, O.-O.P.; Ubah,E.E.; Obasanmi, G. AntioxidantPhytochemicals as Potential Therapyfor Diabetic Complications.Antioxidants 2023, 12, 123. https://doi.org/10.3390/antiox12010123Academic Editor: Paola VendittiReceived: 30 October 2022Revised: 10 December 2022Accepted: 21 December 2022Published: 4 January 2023Copyright: © 2023 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).antioxidantsReviewAntioxidant Phytochemicals as Potential Therapy forDiabetic ComplicationsOke-Oghene Philomena Akpoveso 1,*, Emeka Emmanuel Ubah 2 and Gideon Obasanmi 3,*1 School of Basic Sciences, All American Institute of Medical Sciences, Black River,Saint Elizabeth Parish JMDEH03, Jamaica2 Department of Biochemistry, Michael Okpara University of Agriculture, Umudike 440109, Nigeria3 Department of Ophthalmology and Visual Sciences, The University of British Columbia,Vancouver, BC V5Z 0A6, Canada* Correspondence: o.akpoveso@gmail.com (O.-O.P.A.); gobasanmi01@qub.ac.uk (G.O.)Abstract: The global prevalence of diabetes continues to increase partly due to rapid urbanizationand an increase in the aging population. Consequently, this is associated with a parallel increase inthe prevalence of diabetic vascular complications which significantly worsen the burden of diabetes.For these diabetic vascular complications, there is still an unmet need for safe and effective alter-native/adjuvant therapeutic interventions. There is also an increasing urge for therapeutic optionsto come from natural products such as plants. Hyperglycemia-induced oxidative stress is centralto the development of diabetes and diabetic complications. Furthermore, oxidative stress-inducedinflammation and insulin resistance are central to endothelial damage and the progression of diabeticcomplications. Human and animal studies have shown that …
has type: Article
is shown at: 10.14288/1.0447537
language: eng
peer review status: Reviewed
provider: Vancouver : University of British Columbia Library
publisher: Multidisciplinary Digital Publishing Institute
publisher DOI: 10.3390/antiox12010123
rights: CC BY 4.0
rights URI: https://creativecommons.org/licenses/by/4.0/
scholar level: Faculty
scholar level: Researcher
subject: diabetic complications
subject: phytochemicals
subject: polyphenols
subject: oxidative stress
subject: diabetic nephropathy
subject: diabetic neuropathy
subject: diabetic retinopathy
subject: antioxidants
type: Text
identifier URI: http://hdl.handle.net/2429/89914